The function of lysine-methylated PCAF molecule

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There exist several methyltransferases targeting histone molecules (HMTase). We previously reported that one of HMTase, Set9, methylates multiple lysine residues of p300/CBP-associated factor (PCAF). To elucidate biological relevance of this PCAF methylation, we examined functional change of PCAF cased by methylation. We found that lysine methylation did not alter stability and self-acethylation of PCAF; however, its acethylation activity to P53 and histone H3 molecules was impaired by this modification. Our results implicate a novel transcription pathway including Set9 and PCAF via multiple lysine methylation.