Pharmacokinetics and pharmacodynamics of Org NC 45

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Org NC 45. one of the non-depolarizing muscle relaxants. has shorter duration of action, and its metabolism is mainly depend on the liver. Pancuronium bromide (PB) is the most widely-used. but Org NC 45 is thought to take place of PB.Eghteen patients were anesthetized with 1% enflurane and 60% nitrous oxide in oxigen. Nine patients were given 0.05 mg/kg Org NC 45. and the other nine patients were given 0.2 mg/kg Org NC 45 as a bolus injection: The neuromuscular effect of Org NC 45 was monitored by measuring the twitch tension of adductor pollicis muscle. The plasma concentration of Org NC 45 was determined by high performance liquid chromatography. Small dose group had significantly smaller distribution half-life and larger peripheral volume. compared with large dose group. Central compartment was almost equivalent to circulating blood volume and steady state distribution volume was almost equivalent to interstitial fluid volume.We could not evaluate the relation between pharmacodvnamic parameters in large dose group. because twitch tension was completely depressed even at 50 min after the administration. In small dose group. there was no correlation between the kinetic parameters of each patient and the time to 25%, 50% recovery of the single twitch tension.