Basic and Clinical research about High Frequency Oscillations (600 Hz)
高频振荡(600 Hz)的基础和临床研究
基本信息
- 批准号:13671568
- 负责人:
- 金额:$ 2.5万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
High frequency oscillations (HFOs) are a burst of spike-like wavelets separated from somatosensory evoked potentials (SEPs) by digital bandpass filters. SEPs are generated by pyramidal cells in the cerebral cortex, while HFOs reflect activities of inhibitory interneurons. One hypothesis states that anesthetic drugs initiate anesthetic action by, enhancement of gamma-aminobutyric acid (GABA) action. Therefore, we investigated the effect of sevoflurane and midazolam on SEPs and HFOs. In Wistar male rats, SEPs and HFOs evoked by direct electric stimulation of the ischiatic nerve were recorded in the soma tosensory cortex1. First, we examined whether ketamine infusion was an appropriate anesthetic method for this investigation. The analgesic effect of ketamine was certified by a planter test with heat radiation, while s bowing no change in the latencies and dose dependently increasing of the amplitudes of SEPs and HFOs. We concluded that ketamine infusion was acceptable2. Sevoflurane inhal … More ation prolonged the latency of SEPs, and caused characteristic biphasic changes of amplitude ; a low concentration of sevoflurane increased the amplitude of SEPs ; a high concentration of sevoflurane decreased the amplitude dose dependently. This phenomenon can be explained as follows : a low concentration of sevoflurane acts on only the cortical level GABA receptors, as a result, excitation of the pyramidal cells could reach the surface of the cortex without decay, because GABA stops diverting flow to dendrites. On the other hand, a high concentration of sevoflurane acts on not only the cortical but also thalamic GABA receptors, and it decreases the amount of afferent excitation3. Midazolam prolonged the latencies of SEPs and HFOs, and the length of prolonged latencies was equal at each peak. The amplitudes of early SEPs did not show any change, whereas those of late S EPs decreased. On the contrary, the amplitudes of all HFOs' peaks were markedly decreased. The action site of midazolam is assumed to be in the thalamus or below it Less
高频振荡(HFO)是由数字带通滤波器从体感诱发电位(SEP)中分离出来的一系列尖峰状小波。SEP由大脑皮层中的锥体细胞产生,而HFO反映抑制性中间神经元的活动。一种假说认为,麻醉药物通过增强γ-氨基丁酸(GABA)的作用来启动麻醉作用。因此,我们研究了七氟烷和咪达唑仑对SEP和HFO的影响。在Wistar雄性大鼠中,直接电刺激坐骨神经诱发的SEP和HFO记录在索马感觉皮层1中。首先,我们检查氯胺酮输注是否是本研究的适当麻醉方法。氯胺酮的镇痛作用由热辐射的植物试验证实,但其镇痛作用不受剂量影响,SEPs和HFO振幅呈剂量依赖性增加。我们得出结论,氯胺酮输注是可接受的2。七氟烷吸入 ...更多信息 低浓度七氟醚使SEP的波幅增加,高浓度七氟醚使SEP的波幅呈剂量依赖性降低。这种现象可以解释如下:低浓度的七氟烷仅作用于皮质水平的GABA受体,因此,锥体细胞的兴奋可以到达皮质表面而不衰减,因为GABA停止将血流转向树突。另一方面,高浓度的七氟烷不仅作用于皮质,还作用于丘脑GABA受体,并降低传入兴奋的量3。咪达唑仑可延长SEP和HFO的潜伏期,且各峰潜伏期延长的时间相等。早期SEPs振幅无明显变化,晚期SEPs振幅降低。相反,所有HFO峰的振幅均显著降低。咪达唑仑的作用部位被认为是在丘脑或其下方。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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YAMAMOTO Ken其他文献
YAMAMOTO Ken的其他文献
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