Genetic approach to elucidate roles of stomach cancer related genes
Genetic approach to elucidate roles of stomach cancer related genes
批准号:
17013066
负责人:
YAMAMOTO Ken
金额:
$39.3万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
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英文摘要
Genome-wide linkage study followed by association analyses on candidate chromosomes revealed stomach cancer-related gene, STCH, on chromosome 21. We indicated that STCH localizes ER and is involved in apoptosis pathway. Somatic mutation was identified in STCH gene in stomach cancer. We demonstrated that the STCH mutation endows anti-apoptotic property to cells. We also identified novel chromosomal aberrations of stomach cancer which will be important targets in future research for better understanding of stomach cancer pathogenesis.
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DOI:
10.1016/j.bbrc.2009.01.185
发表时间:
2009-03
期刊:
Biochemical and biophysical research communications
影响因子:
3.1
作者:
[T. Masatsugu;Ken Yamamoto]
通讯作者:
T. Masatsugu;Ken Yamamoto
DOI:
10.1016/j.bbrc.2005.07.110
发表时间:
2005-09-23
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Aoki, M, Yamamoto, K, Sasazuki, T]
通讯作者:
Sasazuki, T
Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence
在原发性血小板增多症中未发现与 V617F Jak2 同源的 Tyk2 突变,尽管它诱导组成型信号传导和生长因子独立性
DOI:
--
发表时间:
2007
期刊:
Leuk Res. 31(8)
影响因子:
--
作者:
[Shide K, Shimoda K, Kamezaki K, Kakumitsu H, Kumano T, Numata A, Ishikawa F, Takenaka K, Yamamoto K, Matsuda T, Harada M]
通讯作者:
Harada M
全ゲノムを対象とした胃がん発症を規定する遺伝要因の探索
针对整个基因组寻找决定胃癌发展的遗传因素
DOI:
--
发表时间:
2005
期刊:
福岡医学雑誌 96
影响因子:
--
作者:
[Aoki M, Yamamura Y, Noshiro H, Sakai K, Yokota J, Kohno T, Tokino T, Ishida S, Ohyama S, Ninomiya I, Uesaka K, Kitajima M, Shimada S, Matsuno S, Yano M, Hiratsuka M, Sugimura H, Itoh F, Minamoto T, Maehara Y, Takenoshita S, Aikou T, Katai H, Yoshimura K, Aoki M.et al., Aoki M.et al., 山本 健]
通讯作者:
山本 健
医学のあゆみ(癌における大規模snp関連解析の現状)
医学史(癌症中大规模SNP相关分析的现状)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[M. Aoki, K. Yamamoto, T. Sasazuki, 山本健, 山本健, 山本健]
通讯作者:
山本健
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