Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect.

β-TcP海绵是一种很好的支架材料，为骨形态发生蛋白-2构建了一种可降解的支架材料。这些结果表明，生长因子和支架的联合使用在骨再生中是有效的。提示联合应用MSC、BMP-2和--磷酸三钙海绵可有效促进骨再生。根据这五项研究的结果，证明了结合生长因子、细胞和支架的组织工程学的应用促进了骨和关节软骨的再生。因此，未来马骨和关节软骨疾病的临床应用是值得期待的。

β-TCP sponge was an excellent scaffold material, which builds a DDS for BMP-2. Based on these results, it was shown that the combined use of growth factors and scaffolds is effective in bone regeneration. it was suggested that the combined use of MSC, BMP-2 and □-TCP sponge efficiently promoted bone regeneration. Based on the results of the five studies, it was demonstrated that the application of tissue engineering combining growth factors, cells, and scaffolds promoted bone and articular cartilage regeneration. Therefore, future clinical applications to bone and articular cartilage diseases of horses are expected.