Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect.

β-TCP海绵是构建BMP-2 DDS的优良支架材料。以上结果表明，生长因子与支架联合使用可有效促进骨再生。提示MSC、BMP-2和□-TCP海绵联合使用能有效促进骨再生。综合以上五项研究结果，我们发现结合生长因子、细胞和支架的组织工程技术的应用促进了骨和关节软骨的再生。因此，在马骨和关节软骨疾病的临床应用前景广阔。

β-TCP sponge was an excellent scaffold material, which builds a DDS for BMP-2. Based on these results, it was shown that the combined use of growth factors and scaffolds is effective in bone regeneration. it was suggested that the combined use of MSC, BMP-2 and □-TCP sponge efficiently promoted bone regeneration. Based on the results of the five studies, it was demonstrated that the application of tissue engineering combining growth factors, cells, and scaffolds promoted bone and articular cartilage regeneration. Therefore, future clinical applications to bone and articular cartilage diseases of horses are expected.