Bioorganic Studies on Neurotrophic Natural Products

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We have carried out bioorganic chemical studies on four neurotrophic natural products which we found. As results, formal asymmetric synthesis of neovibsanin has been completed, and also its minimum structure unit has been clarified. All seven stereoisomers of talaumdin have been synthesized, resulting in proposing the most active isomer in which all four substituents are deposited down on THP. Moreover, neovibsanin, talaumidin, and penylbutane dimer have been found to enhance neurogenesis in mouse hippocampus. In addition, both the fluorescent and photoaffinity labeling probes of neovibsanin active derivative have been successfully prepared.