Chemical Study on Natural Products Enahncing Neurite Outgrowth

天然产物促进神经突生长的化学研究

• 批准号: 05680516
• 负责人: FUKUYAMA Yoshiyasu
• 金额: $ 1.34万
• 依托单位: Tokushima Bunri University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05680516/
• 关键词: Neurotrophic substance; Neurite outgrowth; 5-Lipoxygenase inhibitor; Sesquiterpene; C6-C3 compound; 1,4-Benzoquinone; Lignan; Xanthone

Search for neurotrophic substances in natural products resulted in the discovery of several new following compounds ; eudesobovatol A,eudeshonokiol B,clovanemagnolol, and caryolanemagnolol from Magnolia obovata, mastiogophorenes A and B from Mastigophora diclados, americanol A and isoamericanol A from Phytolacca americana, garciniaxanthone A from Garcinia subelliptica, illicinone E and tricycloillicinone from Illicium tashiroi.These compounds enhanced not only neurtite outgrowth but also ChAT activity in primary cultured neuron of fetal rat cerebral hemispherer at 10^<-5> - 10^<-7> M.Several new 1,4-benzoquinone derivatives named belamcandaquione, and ardisiaquinones A,D,E,and F were found as potent 5-lipoxygenase inhibitors from Belamcanda chinensis and Ardisia sieboldii, respectively.All of them were practically synthesized from the common intermediate, which was coupled via an acetylene unit.

在天然产物中寻找神经营养物质导致了以下几种新的化合物的发现；乳香酚A、乳香酚B、丁香马格诺酚和丁香马格诺酚，乳香酚A和B，美洲植物的美洲醇A和异美洲醇A，藤黄黄酮A，伊利酮E和三环伊利酮。这些化合物在10^<-5> m - 10^<-7> m范围内，不仅能促进神经细胞的生长，还能提高胚胎大鼠大脑半球原代培养神经元的ChAT活性。研究发现，新的1,4-苯醌类衍生物belamcandaquione和ardisiaquinones A、D、E和F分别是有效的5-脂氧合酶抑制剂，它们分别来自belamcananda chinensis和Ardisia sieboldii。它们实际上都是由共同的中间体通过乙炔单元偶联而合成的。

项目成果

Yoshiyasu Fukuyama: "Structure of Magnolianin,A Novel Triilignan Possessing 5-Lipoxygenase Inhibitory Activity" Tetrahedron Letters. 34. 1051-1054 (1993)

Yoshiyasu Fukuyama：“木兰素的结构，一种具有 5-脂氧合酶抑制活性的新型 Triilignan”四面体字母。

Yoshiyasu Fukuyama: "New Chlorin-containing Prenylated C6-C3 Compounds Increasing Cholin Acetyltransferase Activity in Culture of the Postnatal Rat Septal Neurons from Illicium tashiroi" Chem. Pharm. Bull.42. 2199-2201 (1994)

Yoshiyasu Fukuyama：“新的含二氯乙烯异戊二烯化 C6-C3 化合物可提高产后大鼠田代八角隔膜神经元培养物中胆碱乙酰转移酶的活性”Chem。

Y.Fukuyama: "Antioxidant Xanthones from Garcinia subelliptica" Phytochemistry. 36. 501-506 (1994)

Y.Fukuyama：“来自藤黄果的抗氧化剂氧杂蒽酮”植物化学。

Y.Fukuyama, Y.Otoshi, K.Miyoshi, K.Nakamura, M.Kodama, M.Nagasawa, T.Hasegawa, H.Okazaki, and M.Sugawara: "Neurotrophic Sesquiterpene-neolignans from Magnolia obovata : Structures and Neurotrophic Activity" Tetrahedron. 48. 377-392 (1992)

Y.Fukuyama、Y.Otoshi、K.Miyoshi、K.Nakamura、M.Kodama、M.Nagasawa、T.Hasekawa、H.Okazaki 和 M.Sukawara：“来自木兰的神经营养倍半萜-新木脂素：结构和神经营养活性

Y.Fukuyama, Y.Otoshi, K.Miyoshi, N.Hasegawa, and M.Kodama: "Structure of Magnolianin, A Novel Triilignan Possessing 5-Lioxygenase Inhibitory Activity" Tetrahedron Lett.34. 1051-1054 (1993)

Y.Fukuyama、Y.Otoshi、K.Miyoshi、N.Hasekawa 和 M.Kodama：“木兰苷的结构，一种具有 5-加氧酶抑制活性的新型 Triilignan”四面体 Lett.34。