Exploring the novel cycloocygenase-inhibition-independent effects of indomethacin

本项目已开始阐明吲哚美辛抑制花生四烯酸摄取的机制。在这个项目中，我们已经阐明了花生四烯酸的摄取的详细机制，以及通过吲哚美辛治疗人结肠癌细胞对人EP2受体的拮抗作用。此外，我们已经表明，吲哚美辛可以诱导人肺癌细胞上皮间质转化。此外，我们还发现吲哚美辛可减少小鼠脂肪细胞新合成的甘油三酯。由于我们已经开始研究新合成的吲哚化合物对癌细胞的影响，我们相信我们通过该项目获得的发现可以应用于未来寻找癌症治疗新药的项目。

This project had started to elucidate the mechanisms of the inhibitory effects of indomethacin on arachidonic acid uptake. In this project, we have elucidated the detailed mechanisms of the uptake of arachidonic acid as well as the antagonistic effect on human EP2 receptors by indomethacin treatments in human colon cancer cells. Additionally, we have shown that indomethacin can induce epithelial-mesenchymal transition in human lung cancer cells. Moreover, we have indicated that indomethacin could reduce the newly synthesis of the triglyceride in mouse adipocyte. Since we have already started to investigate the effects of newly synthesized indole-compounds on cancer cells, we believe that the findings we have obtained through the project can be applied to the future project for finding novel drugs for cancer therapy.