Improvement of metabolic syndrome by altering molecular species composition of serum free fatty acid

血清FEY脂肪酸，特别是棕榈酸(PA)可在体内诱导Maca RH7777细胞和大鼠内质网应激标志物的表达，而油酸、棕榈油酸和顺式维甲酸的作用弱于PA。在体内PA诱导的肝脏内质网应激反应可被Cofibria酸保护。结果提示，肝脏内质网应激可通过降低游离脂肪酸，尤其是棕榈酸的水平来保护

Serum fee fatty acid, especially palmitic acid (PA) is shown to induce endoplasmic reticulum stress marker expression, both in MacA RH7777 cells, and rats in vivo, while the effects of oleic acid, palmitoleic acid and cis-vaccenic acid were faint compared to PA. The induction of ER stress in liver induced by PA in vivo was protected by pretreatment of cofibric acid. The results suggested that hepatic ER stress is protected by reducing the levels of free fatty acid, especially palmitic acid