Improvement of metabolic syndrome by altering molecular species composition of serum free fatty acid

在MacA RH7777细胞和大鼠体内，血清脂肪酸，特别是棕榈酸（PA）显示诱导内质网应激标志物表达，而油酸、棕榈油酸和顺式异油酸的作用与PA相比微弱。在体条件下，原花青素预处理对PA诱导的肝脏ER应激有保护作用。结果提示，肝内质网应激通过降低游离脂肪酸，尤其是棕榈酸水平而得到保护

Serum fee fatty acid, especially palmitic acid (PA) is shown to induce endoplasmic reticulum stress marker expression, both in MacA RH7777 cells, and rats in vivo, while the effects of oleic acid, palmitoleic acid and cis-vaccenic acid were faint compared to PA. The induction of ER stress in liver induced by PA in vivo was protected by pretreatment of cofibric acid. The results suggested that hepatic ER stress is protected by reducing the levels of free fatty acid, especially palmitic acid