Human brown adipose tissue: activation by cold stimulation and energy expenditure

人类棕色脂肪组织：冷刺激和能量消耗激活

• 批准号: 22590227
• 负责人: SAITO Masayuki
• 金额: $ 2.83万
• 依托单位: Tenshi College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590227/
• 关键词: 褐色脂肪組織; エネルギー消費; 寒冷刺激; 肥満; FDG-PET; カプシノイド; 褐色脂肪; ネルギー消費; 加齢; 体温調節

Brown adipose tissue (BAT), a site of metabolic thermogenesis, is known in small rodents to contribute to the regulation of body temperature, whole-body energy expenditure, and body fat. We have established that human BAT can be identified and assessed by fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT). In this study, we demonstrated that BAT of healthy adult volunteers was activated by acute cold exposure, in parallel with an increase in whole-body energy expenditure. BAT activity was decreased with age, being inversely related to body fat content. In addition to cold stimulation, non-pungent capsaicin analogs (capsinoids) also activated BAT via a transient receptor potential channel (TRP), leading a reduction of body fat.In conclusion, human BAT contributes to the regulation of energy expenditure and body fat content, and thereby is a hopeful therapeutic target to combat obesity.

棕色脂肪组织（BAT）是一种代谢产热的部位，已知在小型啮齿动物中有助于调节体温、全身能量消耗和体脂。我们已经确定，人类BAT可以通过氟脱氧葡萄糖-正电子发射断层扫描/计算机断层扫描（FDG-PET/CT）进行鉴定和评估。在这项研究中，我们证明了健康成年志愿者的BAT被急性寒冷暴露激活，同时全身能量消耗增加。BAT活性随年龄的增长而下降，与体脂含量呈负相关。除了冷刺激，非刺激性辣椒素类似物（类辣椒素）也通过瞬时受体电位通道（TRP）激活BAT，导致体脂减少。总之，人体BAT有助于调节能量消耗和体脂含量，因此有望成为对抗肥胖的治疗靶点。

项目成果

体温・体脂肪調節における褐色脂肪の役割

棕色脂肪在调节体温和体脂方面的作用

• 发表时间: 2010
• 期刊: 臨床体温
• 作者: Orikasa;C.;Kondo;Y.;Usui;S.;Sakuma;Y.;斉藤昌之
• 通讯作者: 斉藤昌之

特別講演:ヒトの褐色脂肪:活性化によるエネルギー消費と肥満予防

特别讲座：人类棕色脂肪：通过激活能量消耗和预防肥胖

• 发表时间: 2010
• 作者: Sujino M;Furukawa K;Koinuma S;Fujioka A;Nagano M;Iigo M;Shigeyoshi Y.;Saito M;遠藤知子・渡辺亜香沙・近藤保彦;Sujino M;千本隆志・小林由紀・近藤保彦・川口真以子;Kadota Kana;斉藤昌之
• 通讯作者: 斉藤昌之

Brown adipose tissue protects against age-related increase in Adiposity in humans

棕色脂肪组织可防止人类与年龄相关的肥胖增加

• 发表时间: 2010
• 作者: Saito M;Yoneshiro T;Aita S;Matsushita M;Kawai Y;Okamatsu-Ogura Y
• 通讯作者: Okamatsu-Ogura Y

Brown adipose tissue is involved in thermogenic effects of capsinoids in humans

棕色脂肪组织参与人体辣椒素的产热作用

• 发表时间: 2010
• 作者: Yoneshiro T;Aita S;Kawai Y;Furuhata Y;Saito M
• 通讯作者: Saito M

褐色脂肪組織の基礎と臨床

棕色脂肪组织的基础知识和临床方面

• 发表时间: 2013
• 期刊: 最新医学
• 作者: Hiromasa Funato;Makito Sato;Christopher M. Sinton;Laurent Gautron;S. Clay Williams;Joel K. Elmquist;Masaru Kuroda;Arthur I. Skoultchi;Masashi Yanagisawa;斉藤昌之
• 通讯作者: 斉藤昌之