Hypothalamus, sympathetic nerve and brown adipose tissue in the regulation of energy balance.
下丘脑、交感神经和棕色脂肪组织参与能量平衡的调节。
基本信息
- 批准号:63570132
- 负责人:
- 金额:$ 1.34万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1988
- 资助国家:日本
- 起止时间:1988 至 1989
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Brown adipose tissue (BAT) is known as a major site for chemical thermogenesis during cold acclimation and spontaneous hyperphagia. It has been proposed that the impairment of BAT thermogenesis is a factor contributing to the development of obesity. In this project, we studied regulatory roles of the hypothalamus and sympathetic nervous system for BAT thermogenesis-linked metabolism in rats.1. Electrical stimulation of the ventromedial nucleus of the hypothalamus (VMH) elicited an increase in norepinephrine turnover in the interscapular BAT, an index of sympathetic nerve activity in this tissue, in parallel with a specific increase in BAT temperature and glucose utilization. The thermogenic response to VMH stimulation was completely abolished after surgical sympathetic denervation. These results indicate that the VMH controls BAT themogenesis through the action of sympathetic nervous system.2. Rats with lesions in the VMH became hyperphagia and obese. In these animals, metabolic and thermogenic activities of BAT were remarkably decreased, supporting an idea that impaired BAT thermogenesis contributes to the development of hypothalamic obesity.3. Rats fed intragastrically, compared with those fed orally, showed lower BAT thermogenic activity and got more obese, although they were given the same amount of food. The results suggest a stimulatory role of oropharyngeal sensations for BAT thermogenesis.
棕色脂肪组织(BAT)是冷适应和自发性摄食过程中化学产热的主要部位。已经提出BAT产热的受损是导致肥胖发展的因素。在本项目中,我们研究了下丘脑和交感神经系统对大鼠BAT产热相关代谢的调节作用。1.电刺激下丘脑腹内侧核(VMH)引起肩胛间BAT中去甲肾上腺素周转率的增加,这是该组织中交感神经活动的指数,与BAT温度和葡萄糖利用率的特定增加平行。手术切除交感神经后,对VMH刺激的产热反应完全消失。这些结果表明VMH通过交感神经系统的作用控制BAT的发生. VMH损伤的大鼠出现暴食和肥胖。在这些动物中,BAT的代谢和产热活性显著降低,支持BAT产热功能受损有助于下丘脑肥胖的发展.与经口喂食的大鼠相比,灌胃喂食的大鼠表现出较低的BAT产热活性,并且变得更肥胖,尽管它们得到的食物量相同。结果表明口咽感觉对BAT产热具有刺激作用。
项目成果
期刊论文数量(19)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Y.Minokoshi: "Sympathetic activation of lipid synthesis in brown adipose tissue in the rat" J.physiol.398. 361-370 (1988)
Y.Minokoshi:“大鼠棕色脂肪组织中脂质合成的交感神经激活”J.physiol.398。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Y. Minokoshi, M. Saito and T. Shimazu: "Sympathetic activation of lipid synthesis in brown adipose tissue in the rat." J.Physiol.398. 361-370 (1988)
Y. Minokoshi、M. Saito 和 T. Shimazu:“交感神经激活大鼠棕色脂肪组织中的脂质合成。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
M.Saito: "Accelerated norepinephrine turnover in peripheral tissues after ventromedial hypothalamic stimulation in rats." Brain Res.481. 298-303 (1989)
M.Saito:“大鼠下丘脑腹内侧刺激后,外周组织去甲肾上腺素周转加速。”
- DOI:
- 发表时间:
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- 影响因子:0
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SAITO Masayuki其他文献
SAITO Masayuki的其他文献
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{{ truncateString('SAITO Masayuki', 18)}}的其他基金
Human brown adipose tissue: activation by cold stimulation and energy expenditure
人类棕色脂肪组织:冷刺激和能量消耗激活
- 批准号:
22590227 - 财政年份:2010
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular and cellular characteristics of brown
棕色的分子和细胞特征
- 批准号:
15081201 - 财政年份:2003
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Brain interleukin-1 as a mediator of stress responses
脑白细胞介素 1 作为应激反应的调节剂
- 批准号:
09460132 - 财政年份:1997
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
New anti-obesity and anti-diabetic druges for dogs activating brown adipose tissue thermogenesis.
用于狗的新型抗肥胖和抗糖尿病药物,可激活棕色脂肪组织生热作用。
- 批准号:
07556117 - 财政年份:1995
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Neuroendocrine mechanism of stress-induced immunosuppression and roles of cytokines.
应激诱导免疫抑制的神经内分泌机制及细胞因子的作用。
- 批准号:
07456128 - 财政年份:1995
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Molecular mechanisms of the central actions of interleukin-1
IL-1 中枢作用的分子机制
- 批准号:
05454116 - 财政年份:1993
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Chronobiological approach to total parenteral nutrition.
全肠外营养的时间生物学方法。
- 批准号:
60570132 - 财政年份:1985
- 资助金额:
$ 1.34万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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