Chronobiological approach to total parenteral nutrition.

全肠外营养的时间生物学方法。

• 批准号: 60570132
• 负责人: SAITO Masayuki
• 金额: $ 0.26万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1986
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570132/
• 关键词: Parenteral nutrition; 生体リズム; 栄養投与パターン

To clarify the effects of nutrient administration pattern on circadian rhythms, body temperature, urine volume and blood hormone levels were measured at 4-hour intervals for 24 hours in patients receiving total enteral nutrition (TEN) with a liquid diet. The patients were divided into two groups, and the diet was continuously given through a day in continuous TEN group, whereas from 8 a.m. to 8 p.m. in cyclic TEN group.In cyclic TEN group, all circadian rhythms examined were nearly normal: that is, body temperature was low in the morning and high in the evening, urinary excretion was less in the morning, and plasma cortisol level was highest in the early morning and lowest in the evening. In contrast, in continuous TEN nutrition, there was no significant circadian rhythmic change in all parameters except urinary excretion. The urine volume showed a normal rhythm regardless of the pattern of nutrient infusion.It was concluded that the pattern of nutrient intake is important for generation and maintenance of normal circadian rhythms and that cyclic TEN is more adequate, at least from a chronobiological standpoint, than continuous TEN, especially when patients were kept under TEN for a long period.

为了阐明营养给药模式对昼夜节律的影响，我们在24小时内每隔4小时测量一次接受全肠内营养（TEN）和液体饮食的患者的体温、尿量和血液激素水平。将患者分为两组，连续TEN组为连续给药一天，循环TEN组为早8点至晚8点。在循环TEN组中，所有昼夜节律检查均接近正常：即体温早低晚高，晨尿量少，血浆皮质醇水平清晨最高，傍晚最低。相比之下，在连续TEN营养中，除尿排泄外，所有参数均无明显的昼夜节律变化。无论输注何种方式，尿量均显示出正常的节律。综上所述，营养摄入模式对正常昼夜节律的产生和维持至关重要，至少从时间生物学的角度来看，循环TEN比连续TEN更充足，特别是当患者长期处于TEN状态时。

项目成果

H. Kato: "Effects of cyclic and continuous total enteral nutrition on circadian cortisol rhythm." J. Clin. Biochem. Nutr.2. (1987)

H. Kato：“循环和连续全肠内营养对昼夜皮质醇节律的影响。”

M. Saito: "Biological rhythms and nutrition." Eiyo-Nippon. 28. 35-42 (1985)

M. Saito：“生物节律和营养。”

斉藤昌之: 栄養日本. 28. 35-42 (1985)

齐藤雅之：日本营养学 28. 35-42 (1985)

Masayuki Saito: "Circadian Clocks and Zeitgebers" Hokkaido Univ.Press, 190(10) (1985)

Masayuki Saito：“昼夜节律时钟和时间”北海道大学出版社，190（10）（1985）

西村浩治: 外科と代謝・栄養. 20. 164-171 (1986)

Koji Nishimura：外科、新陈代谢和营养。20. 164-171 (1986)