Redox regulation of endoplasmic reticulum stress and signals by reactive oxygen species

我们通过使用Prx4基因敲除小鼠分析了Prx4的作用，并获得了以下结果。(1)存在睾丸特异性Prx4转录本，这表明该变体在精子发生中的潜在作用。（2）对Prx 4缺陷型B细胞的分析表明Prx 4在IgM的氧化折叠中起重要作用。(3)发现Prx4抑制由粒细胞集落刺激因子刺激的细胞生长。(4)缺乏Ero1和Prx4的小鼠由于缺乏维生素C而患上坏血病。因此，我们正在逐步揭示Prx4的细胞内和细胞外功能。

We have analyzed roles of Prx4 by using Prx4-knockout mice and obtained following results. (1) Testes-specific Prx4 transcript was present, which suggests potential role of the variant in spermatogenesis.(2)Analyses of Prx4-deficient B cells indicated a significant role of Prx4 in oxidative folding of IgM.(3) Prx4 was found to suppress the cell growth stimulated by granuloctye-colony stimulating factor. (4) Mice that lack Ero1 and Prx4 became scurvy due to vitamin C deficiency. Thus we are gradually unveiling intra-and extra-cellular functions of Prx4.