The approach of synthetic steroid ceragenin to curative medicine for infectious diseases

Ceragenin(CsA)是一种具有甾体环的抗菌物质。CsA覆盖并混合到牙科材料中。通过在培养液中的渗出，控制细菌生物膜在表面的形成，抑制细菌在液体中的生长。即使葡萄球菌在低浓度CsA中反复培养，也不能诱导细菌耐药。CsA通过诱导癌细胞凋亡显示其抗肿瘤活性。

Ceragenin (CSA) is the antibacterial material which has a steroid ring. CSA covered and mixed to a dental material. It controlled to bacterial biofilm formation on those surfaces and inhibited the bacterial growth in liquid by exuding in culture solution. Moreover, a bacterial resistant was not induced, even if staphylococcus was cultivated repeatedly in low-concentration of CSA. CSA showed the antitumor activity by inducing apoptosis to cancer cells.