Pathophysiologial role of Helicobacter pylori asparaginase

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Helicobacter pylori sparaginase exhibited striking cytotoxic activity against U937 cells via asparagine deprivation. The cytotoxic activity of live H. pylori cells against U937 cells was significantly diminished by deletion of the asparaginase gene. An asparaginase-deficient mutant strain was significantly less capable of colonizing Mongolian gerbils. H. pylori cells incorporated extracellular asparagine by transporting aspartate produced by the action of the asparaginase. H. pylori asparaginase may be involved in inhibition of normal lymphocyte function at the gastric niche, allowing H. pylori to evade the host immune system.