The expression of Toll-like receptor in myelodysplastic syndrome

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Myelodysplastic syndrome (MDS) is a clonal disease, characterized by ineffective hematopoiesis due to apoptosis of blood cells, progression to acute leukemia, and high frequency of autoimmune disease complications. Toll-like receptors (TLR) is reported to be involved in apoptosis, tumor immunity, and autoimmune disease. According to these, it is suspected that TLRs are associated with the pathogenesis of MDS. Twenty-one patients with MDS are included in this study. TLRs may be associated with the apoptosis of blood cells in high-risk MDS patients; however not be involved in the progression of MDS to leukemia.