The relation between changes of ApoE-rich HDL subclasses and reactivity to HDL-C homogenous assay

富含 ApoE 的 HDL 亚类的变化与 HDL-C 均质测定反应性之间的关系

• 批准号: 22590535
• 负责人: HIRAYAMA Satoshi
• 金额: $ 2.83万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590535/
• 关键词: ApoE-rich HDL; HDL-C ホモジニアス法; 脂質異常症; 非変性二次元電気泳動; HDL-Cホモジニアス法

High-density lipoprotein (HDL) has several subclasses which abundantly or poorly contain apolipoprotein E (ApoE-rich or ApoE-poor HDL). We investigated the distribution and stability of HDL subclasses during the short-term or long-term storage using native2-dimensional gel electrophoresis. The findings are as follows, 1) ApoE-rich HDL consists of the large- and small-particles. 2) Small-particles were converted into large-particles after 4h-storage at 37℃. 3) Small-particles were decreased or increased, and large-particleswere slightly increased after long-term storage even at 4℃. These findings suggest that LCAT activity may change the composition of ApoE-rich HDL subclasses during storage.

高密度脂蛋白（HDL）具有几个绝对含有载脂蛋白E（富含ApoE或Apoe-Poor HDL）的亚类。我们使用天然2维凝胶电泳在短期或长期存储期间研究了HDL亚类的分布和稳定性。结果如下，1）富含ApoE的HDL由大型和天线组成。 2）在4h存储37℃时，将天粒子转化为大粒子。 3）小粒子减少或增加，并且在长期存储后，大粒子即使在4℃时也会略有增加。这些发现表明，LCAT活性可能会改变储存过程中富含APOE的HDL亚类的组成。

项目成果

2型糖尿病患者において食後トリグリセリドの連続10回平均値は頸動脈硬化症の独立した危険因子である

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• 发表时间: 2011
• 作者: 出居真由美;ほか
• 通讯作者: ほか

Circadian change of serum concentration of small dense LDL-cholesterol in type 2 diabetic patients

• DOI: 10.1016/j.cca.2009.11.017
• 发表时间: 2010-02-02
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Hirayama, Satoshi;Soda, Satoshi;Miida, Takashi
• 通讯作者: Miida, Takashi

アルツハイマー病と可溶性LR11

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• 发表时间: 2010
• 作者: 出居真由美;ほか;平山哲
• 通讯作者: 平山哲

The effects of ezetimibe on postprandial hyperlipidemia and endothelial function in patients with type II b hyperlipidemia

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• 发表时间: 2011
• 作者: Yoshifumi Fukushima;Satoshi Hirayama;et al
• 通讯作者: et al

Non-high-density lipoprotein cholesterol is a practical predictor of long-term cardiac death after coronary artery bypass grafting

• DOI: 10.1016/j.atherosclerosis.2011.12.012
• 发表时间: 2012-03-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Fukushima, Yoshifumi;Ohmura, Hirotoshi;Daida, Hiroyuki
• 通讯作者: Daida, Hiroyuki