Development of Calcium Phosphate Cement as a Dual Cure Type Pulp Capping Agent

双固化型盖髓剂磷酸钙水泥的研制

• 批准号: 14571823
• 负责人: HIRAYAMA Satoshi
• 金额: $ 1.98万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571823/
• 关键词: calcium phosphate cement; pulp capping agent; dual cure type; dentin adhesive system; 裏層剤; デュアルキュアー; 裏層材; 燐酸カルシウムセメント; 生体材料

In the application of the calcium phosphate cement (CPC) as a direct-pulp-capping agent to the dentin-pulp complex, it is necessary to use a CPC that is dentin-adhesive, which completes the setting as soon as possible without spoiling the biocompatibility and the mechanical properties of CPC.We first attempted to develop a CPC as a dual cure-type direct-pulp-capping agent that possesses a light cure system in addition to the setting reaction. The AQ Bond Plus【○!R】 bonding agent (AQP), a commercial one-step bonding system, was used as the liquid phase. AQP provided CPC with a light setting mechanism, resulting in a marked reduction in the setting time. However, its mechanical strength in the initial stage of setting and its conversion to hydroxyapatite (HA) were lower than those of the usual CPCs. These results suggest that further investigation is necessary regarding the monomer type, and water content of the polymerization initiator, to prevent interference with the HA conversion.We then investigated the adhesive strength of the CPC with various composite resin adhesive systems. The results show that the phosphate ester adhesive monomers produce significantly higher adhesive strengths than the carboxylic adhesive monomers. This may be because the -phosphate ester monomers, whose ability of dissolution against inorganic components is stronger than that of carboxylic monomers, reached the deep part by dissolving the CPCs. Based on these results, therefore, it is necessary to conduct further investigation regarding the mechanical properties of CPC, the composition of the set CPC, the difference from adhesive agents in the chemical reaction, etc.Thus, these experiments with a dual cure-type direct-pulp-capping agent that was produced using CPC and an AQP as a liquid phase promote the understanding of the adhesiveness of CPC with resins and its basic properties. It also suggests the possibility of the clinical application of this CPC.

在将磷酸钙水泥（CPC）作为直接盖髓剂应用于牙本质-牙髓复合体时，需要使用具有牙本质粘合剂的CPC，这样可以在不破坏CPC的生物相容性和机械性能的情况下尽快完成凝固。我们首先尝试开发一种具有光固化功能的双固化型直接盖髓剂CPC 系统除了凝结反应。 AQ Bond Plus【○！R】键合剂（AQP）是一种商用一步键合系统，用作液相。 AQP为CPC提供了光定型机制，从而显着缩短了定型时间。然而，其在凝固初始阶段的机械强度和羟基磷灰石（HA）的转化率低于通常的CPC。这些结果表明，有必要对聚合引发剂的单体类型和水含量进行进一步研究，以防止对 HA 转化的干扰。然后，我们研究了 CPC 与各种复合树脂粘合剂体系的粘合强度。结果表明，磷酸酯粘合剂单体比羧酸粘合剂单体产生明显更高的粘合强度。这可能是因为β-磷酸酯单体对无机组分的溶解能力强于羧酸单体，通过溶解CPC到达深层。因此，基于这些结果，有必要对CPC的机械性能、固化后的CPC的组成、化学反应中与粘合剂的差异等进行进一步研究。因此，这些使用CPC和AQP作为液相生产的双固化型直接盖浆剂的实验促进了对CPC与树脂的粘合性及其基本性能的理解。这也提示了该CPC临床应用的可能性。