Development of Calcium Phosphate Cement as a Dual Cure Type Pulp Capping Agent

双固化型盖髓剂磷酸钙水泥的研制

基本信息

批准号：
14571823
负责人：
HIRAYAMA Satoshi
金额：
$ 1.98万
依托单位：
Nihon University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

In the application of the calcium phosphate cement (CPC) as a direct-pulp-capping agent to the dentin-pulp complex, it is necessary to use a CPC that is dentin-adhesive, which completes the setting as soon as possible without spoiling the biocompatibility and the mechanical properties of CPC.We first attempted to develop a CPC as a dual cure-type direct-pulp-capping agent that possesses a light cure system in addition to the setting reaction. The AQ Bond Plus【○!R】 bonding agent (AQP), a commercial one-step bonding system, was used as the liquid phase. AQP provided CPC with a light setting mechanism, resulting in a marked reduction in the setting time. However, its mechanical strength in the initial stage of setting and its conversion to hydroxyapatite (HA) were lower than those of the usual CPCs. These results suggest that further investigation is necessary regarding the monomer type, and water content of the polymerization initiator, to prevent interference with the HA conversion.We then investigated the adhesive strength of the CPC with various composite resin adhesive systems. The results show that the phosphate ester adhesive monomers produce significantly higher adhesive strengths than the carboxylic adhesive monomers. This may be because the -phosphate ester monomers, whose ability of dissolution against inorganic components is stronger than that of carboxylic monomers, reached the deep part by dissolving the CPCs. Based on these results, therefore, it is necessary to conduct further investigation regarding the mechanical properties of CPC, the composition of the set CPC, the difference from adhesive agents in the chemical reaction, etc.Thus, these experiments with a dual cure-type direct-pulp-capping agent that was produced using CPC and an AQP as a liquid phase promote the understanding of the adhesiveness of CPC with resins and its basic properties. It also suggests the possibility of the clinical application of this CPC.

在将磷酸钙水泥（CPC）应用于Dentin-Pulp复合物中的直接脉络膜限制剂时，有必要使用具有牙本质粘合剂的CPC，该CPC尽快完成了设置，该设置尽可能尽快完成，而无需破坏CPC的生物相容性，并且首先尝试了CPC的机械性能。除了设置反应外。 AQ Bond Plus【○！r键合剂（AQP）是一种商业的单步键系统，用作液相。 AQP为CPC提供了灯光设置机制，从而导致设置时间的明显减少。但是，其在设置的初始阶段的机械强度及其转化为羟基磷灰石（HA）的强度低于通常的CPC。这些结果表明，关于单体类型和聚合引发剂的水含量是必要的，以防止干扰HA转化。然后，我们研究了CPC使用各种复合树脂粘合剂系统的粘合强度。结果表明，磷酸酯粘附单体比羧基粘合剂单体产生的粘合强度明显更高。这可能是因为 - 磷酸酯单体的溶解能力强于羧基单体的能力强，但通过溶解CPC来达到深部。因此，基于这些结果，有必要进行有关CPC的机械性能，集合CPC的组成，化学反应中粘合剂的组成的进一步研究，这些实验是使用双重治疗型直接Pulp-Pulp-Pulp限定剂进行的，这些实验是使用CPC和AQP和液体相位促进CPC和CPC的液体相位效率的。还表明了该CPC临床应用的可能性。