Effects of renal function on physical function, functional capacity of ADL, and quality of life in Japanese pre-frail elderly by intervention study

eGFR < 60.0 ml/min/1.73m2的发生率为24.3%,25(OH)D < 75 nmol/L的发生率为86.4%。补充eGFR前期、25(OH)D前期和维生素D与运动能力和肌肉力量的改善显著相关。我们的数据表明，评估肾功能和维持适当的维生素D水平似乎对体弱前老年人的独立生活很重要，提高25(OH)D水平可能需要改善肌肉力量而不是活动能力；如果可能，25(OH)D水平最好大于67.5 nmol/L。

The prevalence of eGFR < 60.0 ml/min/1.73m2was about 24.3%, and that of 25(OH)D < 75 nmol/L was 86.4%. Pre eGFR, pre 25(OH)D, and vitamin D supplementationwere significantly associated with improvement of mobility and muscle power. Our data suggest that assessment of renal function and maintaining appropriate vitamin D levels seem to be significant for independent living in the pre-frail elderly and higher 25(OH)D level might be needed for improvement of muscle strength than mobility; if possible, a 25(OH)D level greater than 67.5 nmol/L is preferable.