Study on the evaluation of new biomarker's predictability of the onset of atherothrombosis

对468份6年前首次随访的队列研究保存血清进行S100A12蛋白和补体成分C3a分解产物的测定，并与基线结果进行比较，S100A12和C3a血清浓度的Spearman相关系数为0.504，p值≦为0.0001。S100A12浓度与血清甘油三酯水平及白细胞计数均呈显著正相关。C3a分解产物浓度与高密度脂蛋白、白细胞计数、血糖、糖化血红蛋白、收缩压、舒张压、体重指数的相关系数均显著。现有条件和偶发中风与S100A12或C3a均无显著关联。

Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.