Study on the evaluation of new biomarker's predictability of the onset of atherothrombosis

新生物标志物对动脉粥样硬化血栓形成预测能力的评价研究

• 批准号: 22590601
• 负责人: SAKATA Kiyomi
• 金额: $ 3.08万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590601/
• 关键词: バイオマーカー; アテローム血栓症; 動脈硬化; 診断薬; コホート研究; 脳卒中; 心筋梗塞; 危険因子

Utilizing 468 preserved serums used for cohort studies whose initial follow-up was more than 6 years ago, serum levels of S100A12 protein and breakdown product of complement component C3a were measured, and comparison with their baseline results was made.Spearman’s coefficient of correlation of the serum concentration between S100A12 and C3a was 0.504 with p-value ≦ 0.0001. The correlation coefficients of S100A12 concentration with the level of triglyceride and that with leukocyte counts were significant. The correlation coefficients of the concentration of the breakdown product of C3a with HDL cholesterol level, leukocyte counts, blood sugar level, HbAlc, systolic blood pressure, diastolic blood pressure, and Body Mass Index were also significant. Neither existing condition nor incident stroke had significant association with S100A12 or C3a.

利用468例首次随访超过6年的队列研究保存的血清，测定血清中S100A12蛋白和补体组分C3a分解产物的水平，并与基线结果进行比较。S100A12与C3a血清浓度的Spearman相关系数为0.504，p值≦0.0001。S100A12浓度与甘油三酯水平和白细胞计数有显著的相关系数。C3a分解产物浓度与HDL胆固醇水平、白细胞计数、血糖水平、HbAlc、收缩压、舒张压、体重指数的相关系数也有显著性。现有疾病和卒中事件与S100A12或C3a均无显著相关性。

项目成果

Plasma B-Type Natriuretic Peptide is Useful for Cardiovascular Risk Assessment in Community-Based Diabetes Subjects -Comparison with Albuminuria.

血浆 B 型利钠肽可用于社区糖尿病受试者的心血管风险评估 - 与蛋白尿比较。

• 发表时间: 2012
• 期刊: International Heart Journal
• 影响因子: 1.5
• 作者: Onodera M;Nakamura M;Tanaka F;Takahashi T;Makita S;Ishisone T;Ishibashi Y;Itai K;Onoda T;Ohsawa M;Tanno K;Sakata K;Omama S;Ogasawara K;Ogawa A;Kuribayashi T;Sakamaki K;Okayama A.
• 通讯作者: Okayama A.

東日本大震災被災者健診からみた被災者の健康リスクと循環器疾患罹患状況

从体检看东日本大地震受害者的健康风险和心血管疾病患病率

• 发表时间: 2013
• 作者: Narumi S;Sasaki M;Ohba H;Ogasawara K;Hitomi J;Mori K;OhuraK;Ono A;Terayama Y.;Kozo Tanno;Zao Guo;坂田清美
• 通讯作者: 坂田清美

Comparison of low-density lipoprotein cholesterol concentrations measured by a direct homogeneous assay and by the Friedewald formula in a large community population

• DOI: 10.1016/j.cca.2010.07.034
• 发表时间: 2010-11-11
• 期刊: CLINICA CHIMICA ACTA
• 影响因子: 5
• 作者: Tanno, Kozo;Okamura, Tomonori;Okayama, Akira
• 通讯作者: Okayama, Akira

Influence of the Great East Japan Earthquake and Tsunami 2011 on Occuerrence of Cerebrovascular Diseases in Iwate,Japan.

2011年东日本大地震和海啸对日本岩手县脑血管病发病的影响。

• 发表时间: 2013
• 期刊: Stroke
• 影响因子: 8.3
• 作者: Shinichi Omama;Yoshida Y;Ogasawara K;Ogawa A;Ishibashi Y;Nakamura M;Tanno K;Ohsawa M;Onoda T;Itai K;Sakata K.
• 通讯作者: Sakata K.

LDLC/HDLC比と高感度CRPの層別化による中年男性心筋梗塞発症リスク評価-岩手県北地域コホート研究の平均5.6年の追跡結果から-

通过LDLC/HDLC比率和高敏CRP分层对中年男性心肌梗塞的风险进行评估 - 基于岩手县北部队列研究平均随访5.6年的结果 -

• 发表时间: 2012
• 作者: 坂田清美;他
• 通讯作者: 他