construction of the rapid screening method for the poisonous substances which can be judged during autopsy

尸检可判断有毒物质快速筛查方法的构建

• 批准号: 22590645
• 负责人: INOUE Hiroyuki
• 金额: $ 2万
• 依托单位: National Research Institute of Police Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590645/
• 关键词: 社会医学; 分析科学; 法中毒学; 質量分析; 薬毒物; スクリーニング; 血液; 違法薬物

In the present study, construction of the rapid screening method for the poisonous substances is described. Target substances were chosen from the list of drugs selected as the most important compounds for toxicological analysis in Japan. Human plasma extracts with solid-phase extraction cartridges were determined by an ion-trap mass spectrometer. Collision-induced dissociation of protonated molecules gave characteristic product ion spectra and provided identification of the analytes. Time required for one sample was 5 min or less. The method seems to be useful for rapid screening of the poisonous substances in the practice of forensic science

在本研究中，描述了有毒物质快速筛选方法的构建。目标物质是从日本选定的毒理学分析中最重要的化合物的药物清单中选择的。用离子阱质谱计测定固相萃取筒的人血浆提取物。质子化分子的碰撞诱导解离给出了特征产物离子谱，并提供了分析物的鉴定。一个样品所需的时间为5分钟或更短。该方法对法医鉴定中有毒物质的快速筛选具有一定的实用价值

项目成果

Rapid urinalysis of amphetamines by thermal desorption counter flow introduction atmospheric pressure chemical ionization mass spectrometry.

通过热解吸逆流引入大气压化学电离质谱法快速分析安非他明尿液。

• 发表时间: 2010
• 作者: Inoue;H;et al.
• 通讯作者: et al.

Forensic toxicology-Detection and profiling of drugs and poison-

法医毒理学-药物和毒物的检测和分析-

• 发表时间: 2011
• 作者: Inoue;H
• 通讯作者: H

Differentiation of regioisomeric fluoroamphetamine analogs by gas chromatography.mass spectrometry and liquid chromatography.tandem mass spectrometry

通过气相色谱-质谱联用和液相色谱-串联质谱区分区域异构氟苯丙胺类似物

• DOI: 10.1007/s11419-013-0184-7
• 发表时间: 2013
• 期刊: Forensic Toxicology
• 影响因子: 2.2
• 作者: Nakazono;Y.;Tsujikawa;K.;Kuwayama;K.;Kanamori;T.;Iwata;Y.T.;Miyamoto;K.;Kasuya;F.;Inoue;H
• 通讯作者: H

Drug screening in human plasma using solid phase extraction and direct mass spectrometry

使用固相萃取和直接质谱法在人血浆中进行药物筛选

• 发表时间: 2013
• 作者: Inoue;H.;Nakazono;Y.;Hashimoto;H.;Kuwayama;K.;Tsujikawa;K.;Kanamori;T.,Iwata;Y.T
• 通讯作者: Y.T

Direct analysis of illicit drugs by thermal desorption counter-flow introduction atmospheric pressure chemical ionization mass spectrometry

热解吸逆流引入常压化学电离质谱法直接分析违禁药物

• 发表时间: 2011
• 作者: Inoue;H.;Hashimoto;H.;Iwata;Y.T.;Tsujikawa;K.;Hashimoto;M.;Yokokura;T.;Yamada;M
• 通讯作者: M