Vascular Biological Profile on Endothelial Progenitor Cell Origin and Differentiation

内皮祖细胞起源和分化的血管生物学特征

• 批准号: 22590796
• 负责人: MASUDA Haruchika
• 金额: $ 2.5万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590796/
• 关键词: 血管内皮前駆細胞; 血管再生; 分化; 造血幹細胞; 分化動態解析法; 血液幹細胞; 血管生物学

Circulating endothelial progenitor cell (EPC) is known to possess vascular repair/regeneration ability. However, the origin and differentiation cascade has yet to be elucidated. Our established analytical assay system of EPC expansion and differentiation revealed the functional features of EPC origin and differentiation. The findings provide us the potent information to develop diagnostic and therapeutic strategies for cardiovascular diseases.

循环内皮祖细胞(EPC)具有血管修复/再生能力。然而，其起源和分化级联尚不清楚。我们建立的EPC扩增和分化的分析检测体系揭示了EPC起源和分化的功能特征。这些发现为我们开发心血管疾病的诊断和治疗策略提供了强有力的信息。

项目成果

血管再生治療-現状から未来を展望する-

血管再生治疗-从现状展望未来-

• 发表时间: 2012
• 作者: Prati F;et al.;(7人中13番目);加賀谷豊;増田治史
• 通讯作者: 増田治史

Methodological Development of a Clonogenic Assay to Determine Endothelial Progenitor Cell Potential

• DOI: 10.1161/circresaha.110.231837
• 发表时间: 2011-06-24
• 期刊: CIRCULATION RESEARCH
• 影响因子: 20.1
• 作者: Masuda, Haruchika;Alev, Cantas;Asahara, Takayuki
• 通讯作者: Asahara, Takayuki

Development of in vitro single cell based culture system to assess stem cell fate into endothelial lineage

开发基于体外单细胞的培养系统以评估干细胞向内皮谱系的命运

• 发表时间: 2010
• 作者: Watanabe H;Ohba T;Ito H;増田治史
• 通讯作者: 増田治史

The therapeutic potential of ex vivo expanded CD133+ cells derived from human peripheral blood for peripheral nerve injuries

• DOI: 10.3171/2012.7.jns111503
• 发表时间: 2012-10-01
• 期刊: JOURNAL OF NEUROSURGERY
• 影响因子: 4.1
• 作者: Ohtsubo, Shin;Ishikawa, Masakazu;Ochi, Mitsuo
• 通讯作者: Ochi, Mitsuo

Aberrant kinetics of bone marrow-derived endothelial progenitor cells in the murine oxygen-induced retinopathy model.

• DOI: 10.1167/iovs.10-5880
• 发表时间: 2011-10
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Y. Nakagawa;H. Masuda;Rie Ito;M. Kobori;M. Wada;Tomoko Shizuno;Atsuko Sato;Takahiro Suzuki;K. Kawai;T. Asahara