Exposure to Artificial Sweetener in Juvenile Mice Intensifies Addictionto High-Fat Diet and Exaggerates Leptin Resistance in Adulthood

幼年小鼠接触人工甜味剂会加剧对高脂肪饮食的成瘾，并加剧成年小鼠的瘦素抵抗力

• 批准号: 22591014
• 负责人: YABIKU Kouichi
• 金额: $ 2.83万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591014/
• 关键词: 肥満; レプチン抵抗性; 視床下部; 視床下部小胞体ストレス; 分子シャペロン

Artificial sweeteners during the juvenile period may increase susceptibility to diet-induced obesity in adulthood through the augmentation of ER stress in the hypothalamus. This was confirmed by co-administration of a chemical chaperone with artificial sweeteners, which attenuated hypothalamic ER stress and HFD preference in adulthood. In murine primary neuronal cells, artificial sweeteners substantially augmented the expression of ER stress-related genes, suggesting direct contribution of artificial sweeteners to hypothalamic ER stress.

青少年时期的人工甜味剂可能会通过增强下丘脑的内质网应激而增加成年后对饮食引起的肥胖的易感性。化学伴侣与人工甜味剂的共同给药证实了这一点，该化学伴侣减轻了成年期的下丘脑 ER 应激和 HFD 偏好。在小鼠原代神经元细胞中，人工甜味剂显着增强了内质网应激相关基因的表达，表明人工甜味剂对下丘脑内质网应激有直接贡献。