Exposure to Artificial Sweetener in Juvenile Mice Intensifies Addictionto High-Fat Diet and Exaggerates Leptin Resistance in Adulthood

幼年小鼠接触人工甜味剂会加剧对高脂肪饮食的成瘾，并加剧成年小鼠的瘦素抵抗力

• 批准号: 22591014
• 负责人: YABIKU Kouichi
• 金额: $ 2.83万
• 依托单位: University of the Ryukyus
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591014/
• 关键词: 肥満; レプチン抵抗性; 視床下部; 視床下部小胞体ストレス; 分子シャペロン

Artificial sweeteners during the juvenile period may increase susceptibility to diet-induced obesity in adulthood through the augmentation of ER stress in the hypothalamus. This was confirmed by co-administration of a chemical chaperone with artificial sweeteners, which attenuated hypothalamic ER stress and HFD preference in adulthood. In murine primary neuronal cells, artificial sweeteners substantially augmented the expression of ER stress-related genes, suggesting direct contribution of artificial sweeteners to hypothalamic ER stress.

人工甜味剂在青少年时期可能会增加易感性饮食诱导的肥胖症在成年后，通过增强ER应激下丘脑。这一点得到了证实，共同管理的化学伴侣与人工甜味剂，衰减下丘脑ER应激和HFD偏好在成年期。在小鼠原代神经元细胞中，人工甜味剂显著增强了ER应激相关基因的表达，表明人工甜味剂对下丘脑ER应激的直接贡献。