Exposure to Artificial Sweetener in Juvenile Mice Intensifies Addictionto High-Fat Diet and Exaggerates Leptin Resistance in Adulthood
幼年小鼠接触人工甜味剂会加剧对高脂肪饮食的成瘾,并加剧成年小鼠的瘦素抵抗力
基本信息
- 批准号:22591014
- 负责人:
- 金额:$ 2.83万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (C)
- 财政年份:2010
- 资助国家:日本
- 起止时间:2010 至 2012
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Artificial sweeteners during the juvenile period may increase susceptibility to diet-induced obesity in adulthood through the augmentation of ER stress in the hypothalamus. This was confirmed by co-administration of a chemical chaperone with artificial sweeteners, which attenuated hypothalamic ER stress and HFD preference in adulthood. In murine primary neuronal cells, artificial sweeteners substantially augmented the expression of ER stress-related genes, suggesting direct contribution of artificial sweeteners to hypothalamic ER stress.
人工甜味剂在青少年时期可能会增加易感性饮食诱导的肥胖症在成年后,通过增强ER应激下丘脑。这一点得到了证实,共同管理的化学伴侣与人工甜味剂,衰减下丘脑ER应激和HFD偏好在成年期。在小鼠原代神经元细胞中,人工甜味剂显著增强了ER应激相关基因的表达,表明人工甜味剂对下丘脑ER应激的直接贡献。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
YABIKU Kouichi其他文献
YABIKU Kouichi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('YABIKU Kouichi', 18)}}的其他基金
Mechanisms of developing food preference and memorization (learning) through exposure to high-fat diets or sweeteners early in life
通过生命早期接触高脂肪饮食或甜味剂来发展食物偏好和记忆(学习)的机制
- 批准号:
25461391 - 财政年份:2013
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
相似海外基金
REU Site: Microbial Biofilm Development, Resistance, & Community Structure
REU 网站:微生物生物膜的发展、耐药性、
- 批准号:
2349311 - 财政年份:2025
- 资助金额:
$ 2.83万 - 项目类别:
Continuing Grant
Role of CD206 surface antigen on M2 macrophages in the development of insulin resistance in the diet-induced obese mice model
M2巨噬细胞上CD206表面抗原在饮食诱导肥胖小鼠模型胰岛素抵抗发展中的作用
- 批准号:
24K19282 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Intended and unintended consequences of the ZnO ban from pig diets on antimicrobial resistance, post-weaning diarrhoea and the microbiome
猪日粮中禁用氧化锌对抗菌素耐药性、断奶后腹泻和微生物组的有意和无意的影响
- 批准号:
BB/Y003861/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant
Ecological and Evolutionary Drivers of Antibiotic Resistance in Patients
患者抗生素耐药性的生态和进化驱动因素
- 批准号:
EP/Y031067/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant
Engineering Nature-based Solutions to Tackle Antimicrobial Resistance
工程基于自然的解决方案来解决抗菌素耐药性
- 批准号:
EP/Y003101/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant
The epidemiology of transmissible antimicrobial resistance among Shigella species
志贺菌属中传播性抗菌药物耐药性的流行病学
- 批准号:
MR/X000648/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant
Glutamate-Energetics In Schizophrenia And Treatment Resistance
精神分裂症中的谷氨酸能量学和治疗抵抗
- 批准号:
MR/X021696/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant
RII Track-4: @NASA: Investigation of Erosive Wear Resistance of Ceramic Parts Produced by Additive Manufacturing
RII Track-4:@NASA:增材制造生产的陶瓷零件的耐冲蚀磨损性能研究
- 批准号:
2327252 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Standard Grant
Identification of genes responsible for the resistance to first line anti-myeloma therapeutics
鉴定导致一线抗骨髓瘤治疗耐药的基因
- 批准号:
24K11532 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Turning defects into allies to develop intrinsic resistance to hydrogen-induced fractures (ResistHfracture)
化缺陷为盟友,增强对氢致断裂的内在抵抗力 (ResistHfracture)
- 批准号:
EP/Y037219/1 - 财政年份:2024
- 资助金额:
$ 2.83万 - 项目类别:
Research Grant