The pathoetiology of destruction and regeneration in salivary gland of Sjogren's syndrome

干燥综合征（SS）是一种慢性自身免疫性疾病，其特征是唾液腺和泪腺炎症，导致口干和干眼。再生基因（Reg）最初是作为在再生胰岛中特异性过表达的基因分离的。在这项研究中，我们研究了REG基因的表达在唾液腺（SG）和抗REG自身抗体在SS。这些数据有力地表明，自身免疫REG可能在SG导管上皮细胞的变性SS中发挥作用。

Sjogren’s syndrome (SS) is a chronic autoimmune disease, characterized by inflammation of salivary and lacrimal glands, leading to dry mouth and dry eye. The regenerating gene (Reg) was originally isolated as a gene specifically overexpressed in regenerating pancreatic islets. In this study, we examined the expression of REG genes in the salivary glands (SG) and anti-REG autoantibodies in SS. These data strongly suggest that autoimmunity to REG may play a role in the degeneration of SG ductal epithelial cells in SS.