Pathophysiology and pharmacotherapy in pulmpnary arterial hypertension

平滑肌细胞主要表达中电导钙激活的钾通道（IKca），这种Kca通道表达模式的表型转变引起细胞电特性的显著改变，并产生功能性后果，部分原因是对钙内流的影响。IKca通道的激活有助于平滑肌细胞中的Ca 2+内流，因此在某些病理生理条件下影响迁移和增殖。

Proliferative smooth muscle cells predominantly express intermediate-conductance Ca2+-activated K+ (IKca) channels.This phenotypic shift in the Kca channel expression pattern gives rise to dramatic alterations in the electrical properties of the cell, which have functional consequences, inpart because of the effect on Ca2+ influx. IKca channel activation contributes to Ca2+ entry in smooth muscle cells andtherefore affect migration and proliferation in some pathophysiologic conditions.