Research on mechanism of progression from vasculitis of Kawasaki disease to sclerotic lesion

川崎病血管炎向硬化病变进展机制的研究

• 批准号: 22591188
• 负责人: KAWAI Yoko
• 金额: $ 2.83万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591188/
• 关键词: 小児循環器学; 川崎病; 酸化ストレス; 血小板; 動脈硬化; 血管障害; 抗血小板療法

Inflammation, oxidative stress and vascular endothelial disorder related deeply the onset of vascular disorder and arteriosclerosis. They initiate production of various cytokines and platelet activation, thereby progress disease condition.We examined platelet activation and oxidative stress in acute Kawasaki disease. Oxidativestress and inflammatory markers in IVIG-responder group immediately decreased by IVIG treatment. On the other hand, antioxidant marker of IVIG-nonresponder group in pre-treatment was significantly lower than that of healthy control and IVIG-responder group, and oxidative stress and inflammatory markers maintained high value.Platelet was activated for more six months from the onset of Kawasaki disease. This study showed the evaluation of oxidative stress and activated platelets are useful and have clinical significance.

炎症、氧化应激和血管内皮功能障碍与血管疾病和动脉硬化的发生密切相关。我们检测了急性川崎患者的血小板活化和氧化应激。IVIG反应组的氧化应激和炎症标志物立即降低IVIG治疗。IVIG无应答组治疗前抗氧化指标明显低于健康对照组和IVIG应答组，氧化应激和炎症指标维持在较高水平，血小板活化时间在川崎发病后6个月以上。本研究表明，氧化应激和血小板活化的评估是有用的，具有临床意义。

项目成果

Relationship between Inflammation and Oxidative Stress of Kawasaki Disease in Acute Phase

川崎病急性期炎症与氧化应激的关系

• 发表时间: 2011
• 作者: Toki T;Hayashi Y;脇口宏;Yahata T
• 通讯作者: Yahata T

Dynamics of Reactive Oxygen Metabolites and Biological Antioxidant Potential in the Acute Stage of Kawasaki Disease

• DOI: 10.1253/circj.cj-10-0605
• 发表时间: 2011-10-01
• 期刊: CIRCULATION JOURNAL
• 影响因子: 3.3
• 作者: Yahata, Tomoyo;Suzuki, Chinatsu;Hamaoka, Kenji
• 通讯作者: Hamaoka, Kenji

Relationship between inflammation and oxidative stress in acute Kawasaki disease

急性川崎病炎症与氧化应激的关系

• 发表时间: 2012
• 作者: Dohno T;et al.;檜垣高史;檜垣高史;Yahata T;檜垣高史;Yahata T
• 通讯作者: Yahata T