Research on mechanism of progression from vasculitis of Kawasaki disease to sclerotic lesion

炎症、氧化应激和血管内皮功能紊乱与血管疾病和动脉硬化的发生密切相关。我们检测了急性川崎患者的血小板活化和氧化应激。IVIG反应组的氧化应激和炎症标志物立即降低IVIG治疗。IVIG无应答组治疗前抗氧化指标明显低于健康对照组和IVIG应答组，氧化应激和炎症指标维持在较高水平，血小板活化时间在川崎发病后6个月以上。本研究表明，氧化应激和血小板活化的评估是有用的，具有临床意义。

Inflammation, oxidative stress and vascular endothelial disorder related deeply the onset of vascular disorder and arteriosclerosis. They initiate production of various cytokines and platelet activation, thereby progress disease condition.We examined platelet activation and oxidative stress in acute Kawasaki disease. Oxidativestress and inflammatory markers in IVIG-responder group immediately decreased by IVIG treatment. On the other hand, antioxidant marker of IVIG-nonresponder group in pre-treatment was significantly lower than that of healthy control and IVIG-responder group, and oxidative stress and inflammatory markers maintained high value.Platelet was activated for more six months from the onset of Kawasaki disease. This study showed the evaluation of oxidative stress and activated platelets are useful and have clinical significance.