Mathematic statistical analyses of relationship between severity of neurological symptom and MRI measurements of white matter injury

神经症状严重程度与脑白质损伤 MRI 测量值之间关系的数理统计分析

• 批准号: 22591318
• 负责人: TERAJIMA Kenshi
• 金额: $ 1.83万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591318/
• 关键词: 核磁気共鳴画像(MRI); 大脳白質; 神経症状; 数理統計学; シミュレーション; 磁気共鳴スペクトロスコピー; 一酸化炭素中毒; 白質脳症; ＭＲＳ; 拡散テンソルイメージング; ＤＴＩ; 脳機能解析; 遅発性脳症; 核磁気共鳴画像; MRI; MRS; アルゴリズム; プログラミング; 神経軸索

The purposes of this project are: 1) to develop a computer-based method of characterizing white matter injury; 2) to develop a method of analyzing white matter injury by using modern MR techniques; and 3) to integrate these two methods mathematically and statistically. This report overviews the results of this project as follows. Firstly, we proposed a mathematic statistical model of growth cone behavior that employs multiple sensors designed for simulating the signal transduction system. Secondly, we found biomarkers of disease severity in multiple system atrophy of cerebellar type (MSA-C) by imaging disease specific regions using proton magnetic resonance spectroscopy (1H-MRS) on a 3.0 T system. Finally, we analyzed relationship between severity of clinical symptoms of a patient with white matter injury and MRI measurements of the lesions.

本项目的目的是：1）开发一种基于计算机的表征白色损伤的方法; 2）开发一种使用现代MR技术分析白色损伤的方法; 3）在数学和统计学上整合这两种方法。本报告概述该项目的成果如下。首先，我们提出了一个生长锥行为的数学统计模型，该模型采用多个传感器来模拟信号转导系统。其次，我们通过在3.0 T系统上使用质子磁共振波谱（1H-MRS）对疾病特定区域进行成像，发现了小脑型多系统萎缩（MSA-C）疾病严重程度的生物标志物。最后，我们分析了一位白色损伤患者的临床症状严重程度与病灶MRI测量结果之间的关系。

项目成果

A stochastic model of neuronal growth cone guidance regulated by multiple sensors.

• DOI: 10.1016/j.jtbi.2010.07.036
• 发表时间: 2010-10
• 期刊: Journal of theoretical biology
• 影响因子: 2
• 作者: Taichiro Kobayashi;K. Terajima;M. Nozumi;M. Igarashi;K. Akazawa

Brainstem Myo-inositol as a biomarker of disease severity in MSA-C: A 3T 1H-MRS study

脑干肌醇作为 MSA-C 疾病严重程度的生物标志物：一项 3T 1H-MRS 研究

• 发表时间: 2010
• 作者: Takado Y;Igarashi H;Terajima K;Shimohata T;Ozawa T;Okamoto K;Nishizawa M;Nakada T
• 通讯作者: Nakada T

Economic impact of combination therapy with infliximab plus azathioprine for drug-refractory Crohn's disease: A cost-effectiveness analysis

英夫利昔单抗联合硫唑嘌呤联合治疗药物难治性克罗恩病的经济影响：成本效益分析

• DOI: 10.1016/j.crohns.2012.04.007
• 发表时间: 2013
• 期刊: J Crohns Colitis
• 影响因子: 8
• 作者: Saito S;Shimizu U;Nan Z;Mandai N;Yokoyama J;Terajima K;Akazawa K
• 通讯作者: Akazawa K

神経軸索の成長過程を推定するアルゴリズムの開発

开发估计神经轴突生长过程的算法

• 发表时间: 2010
• 作者: Matsuo S;Nakajima K;Kinuya S;小林太一朗,寺島健史,野住素弘,五十嵐道弘,赤澤宏平
• 通讯作者: 小林太一朗,寺島健史,野住素弘,五十嵐道弘,赤澤宏平

Association of Nitrogen Compounds in Drinking Water with Incidence of Esophageal Squamous Cell Carcinoma in Shexian, China

• DOI: 10.1620/tjem.226.11
• 发表时间: 2012-01-01
• 期刊: TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
• 影响因子: 2.2
• 作者: Zhang, Nan;Yu, Cao;Wang, Shijie
• 通讯作者: Wang, Shijie