Development of adaptive radiotherapy using preliminarily-contouredstrictures and cone-beam CT for daily setup

我们设计了一个初步轮廓系统，用于总肿瘤体积（GTV）评估中的“双读”。尽管存在较小的系统误差，但GTV轮廓的观察者间差异仍然存在；该系统为GTV轮廓的集成提供了一种有价值的方法。基于锥束计算机断层扫描（CBCT）每日设置的处方剂量差异小于5%。初步轮廓系统与cbct衍生的剂量计算相结合，可以提供与各部位解剖变化相匹配的自适应放疗。

We designed a preliminary-contouring system for “double reading”in the gross tumor volume (GTV) assessment. Although there was minor system error,considerable interobserver differences for GTV contouring persisted; our system can bea valuable method for the integration of GTV contouring. The differences in prescribeddoses based on cone-beam computed tomography (CBCT) for daily setup were less than 5%. The combination of the preliminary-contouring system and CBCT-derived dose calculationcan provide adaptive radiotherapy matching with anatomical changes at each fraction.