Role of oxygen-derived free radicals and BubR1 expression
Role of oxygen-derived free radicals and BubR1 expression
氧自由基和 BubR1 表达的作用
批准号：
22591408
负责人：
GUNTANI Atsushi
金额：
$2.83万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
中文摘要
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英文摘要
BubR1 expression and hAoSMC proliferative ability were significantly decreased in the aged hAoSMC. Angiotensin II and H2O2 upregulated BubR1 expression in young hAoSMC, and the upregulation was abrogated by a p38 MAPK inhibitor or an inhibitor of the NADH/NADPH oxidase. siRNA against BubR1 reduced proliferative activity and increased ROS production in hAoSMC. These findings demonstrate BubR1 mRNA expression decreases along with proliferation in aged hAoSMC. Aging-related loss of BubR1 and subsequent impairment of reactivity to ROS may explain reduced proliferative capacity of aged smooth muscle cells.These findings demonstrate BubR1 mRNA expression decreases along with proliferation in aged hAoSMC. Aging-related loss of BubR1 and subsequent impairment of reactivity to ROS may explain reduced proliferative capacity of aged smooth muscle cells.
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会议论文
Reduced expression of the spindle assembly checkpoint protein BubR1 in aged human smooth muscle cells.
衰老的人平滑肌细胞中纺锤体组装检查点蛋白 BubR1 的表达减少。
衰老的人平滑肌细胞中纺锤体组装检查点蛋白 BubR1 的表达减少。
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
[郡谷篤史、前原喜彦, 他]
通讯作者：
他
Reduced expression of the spindle assembly checkpoint protein BubR1 in aged human smooth muscle cells
衰老人平滑肌细胞中纺锤体组装检查点蛋白 BubR1 的表达减少
衰老人平滑肌细胞中纺锤体组装检查点蛋白 BubR1 的表达减少
DOI：
--
发表时间：
2011
期刊：
影响因子：
--
作者：
[Honda M, Yamamoto H, Hayashida S, Suda H, Ohya Y, Lee KJ, Takeichi T, Asonuma K, Inomata Y, Atsushi Guntani]
通讯作者：
Atsushi Guntani
海外基金
