The role of cathepsin E in mammary carcinogenesis and prognosis in breast cancer

组织蛋白酶E是一种与免疫反应相关的内体天冬氨酸氨基转移酶。随着乳腺癌的分期和进展，血清组织蛋白酶E活性显著降低，并与乳腺癌的无病生存和总生存期显著相关。组织蛋白酶E基因缺陷的小鼠频繁地和年龄相关地发展为乳腺肿瘤。组织蛋白酶E控制Wnt5a的适当运输和分泌，从而触发乳腺的正常生长和发育，这是组织蛋白酶E抑制乳腺癌发生的新机制。

Cathepsin E an endosomal aspartic proteinase associated with immune responses. The serum cathepsin E activity was significantly decreased according to the stages and progression in breast cancer, and was significantly associated with disease-free and overall survival. Cathepsin E-deficient mice frequently and age-dependently developed mammary tumors. Cathepsin E controls proper trafficking and secretion of Wnt5a that triggers normal growth and development of mammary glands, representing a novel mechanism whereby cathepsin E can inhibit mammary carcinogenesis.