The role of cathepsin E in mammary carcinogenesis and prognosis in breast cancer

组织蛋白酶E在乳腺癌发生及预后中的作用

• 批准号: 22591438
• 负责人: SUGIURA Hiroshi
• 金额: $ 3.08万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591438/
• 关键词: 乳癌; カテプシン E; 予後因子; カテプシンE

Cathepsin E an endosomal aspartic proteinase associated with immune responses. The serum cathepsin E activity was significantly decreased according to the stages and progression in breast cancer, and was significantly associated with disease-free and overall survival. Cathepsin E-deficient mice frequently and age-dependently developed mammary tumors. Cathepsin E controls proper trafficking and secretion of Wnt5a that triggers normal growth and development of mammary glands, representing a novel mechanism whereby cathepsin E can inhibit mammary carcinogenesis.

组织蛋白酶E是一种与免疫应答相关的内体天冬氨酸蛋白酶。血清组织蛋白酶E活性随着乳腺癌的分期和进展而显著降低，并与无病生存期和总生存期显著相关。组织蛋白酶E缺乏的小鼠经常和年龄依赖性发展乳腺肿瘤。组织蛋白酶E控制Wnt5a的适当运输和分泌，Wnt5a触发乳腺的正常生长和发育，代表组织蛋白酶E可以抑制乳腺癌发生的新机制。