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Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction

Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction
通过抑制血小板-库普弗细胞相互作用预防缺血再灌注肝损伤
批准号:
22591499
负责人:
KONDO Tadashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

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中文摘要
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英文摘要
Hepatic ischemiaereperfusion (I/R) leads to activation of Kupffer cells (KCs). We have evaluate the interaction between platelets and KCs in the hepatic microcirculation after I/R. In the I/R group, the number of adherent platelets increased significantly after I/R. More than 50% of the adherent platelets adhered to KCs. We succeeded in visualizing the dynamics of both KCs and platelets in the hepatic sinusoids. Liver ischemia induced the adhesion of platelets to KCs in the early period, which could play a key role in reperfusion injury of the liver.
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会议论文
肝虚血再潅流時のKupffer細胞と血小板の動態の解明
阐明肝缺血再灌注期间库普弗细胞和血小板的动态
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi., 森田剛文, Ogawa K., 小川光一, 小川光一, 小川 光一, 小川光一, 小川光一, Tamura T., 田村孝史, 田村孝史, 田村孝史, 田村孝史]
通讯作者: 田村孝史
DOI: 10.3109/09537101003637265
发表时间: 2010-01
期刊: Platelets
影响因子: 3.3
作者: [Sugiru Pak;T. Kondo;Y. Nakano;S. Murata;K. Fukunaga;T. Oda;R. Sasaki;N. Ohkohchi]
通讯作者: Sugiru Pak;T. Kondo;Y. Nakano;S. Murata;K. Fukunaga;T. Oda;R. Sasaki;N. Ohkohchi
DOI: 10.1016/j.jss.2011.12.010
发表时间: 2012-11
期刊: The Journal of surgical research
影响因子: --
作者: [Takafumi Tamura;T. Kondo;Sugiru Pak;Y. Nakano;S. Murata;K. Fukunaga;N. Ohkohchi]
通讯作者: Takafumi Tamura;T. Kondo;Sugiru Pak;Y. Nakano;S. Murata;K. Fukunaga;N. Ohkohchi
The influence of the milddegree steatotic liver in ischemia reperfusion injury.
轻度脂肪肝对缺血再灌注损伤的影响。
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi., 森田剛文, Ogawa K.]
通讯作者: Ogawa K.
12
    Three dimensional medical image diagnosis of lung, liver and brain using new artificial neural network
    • 批准号:
      26420421
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.66万
    • 财政年份:
      2014
    • 负责人:
      KONDO Tadashi
    • 依托单位:
    Phase transition of Ice detemined by maganetic measurement
    • 批准号:
      25610156
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2013
    • 负责人:
      KONDO Tadashi
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    Chemical heterogeneity in solid driven by steep temperature gradient under pressure
    • 批准号:
      23654188
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.41万
    • 财政年份:
      2011
    • 负责人:
      KONDO Tadashi
    • 依托单位:
    Integrative omics study on bone metastatic tumors using clinical samples for clinical applications
    • 批准号:
      22501057
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2010
    • 负责人:
      KONDO Tadashi
    • 依托单位:
    海外基金