Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction
Prevention of ischemia-reperfusion liver injury through inhibiting the Platelets-Kuppfer cell interaction
批准号:
22591499
负责人:
KONDO Tadashi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Hepatic ischemiaereperfusion (I/R) leads to activation of Kupffer cells (KCs). We have evaluate the interaction between platelets and KCs in the hepatic microcirculation after I/R. In the I/R group, the number of adherent platelets increased significantly after I/R. More than 50% of the adherent platelets adhered to KCs. We succeeded in visualizing the dynamics of both KCs and platelets in the hepatic sinusoids. Liver ischemia induced the adhesion of platelets to KCs in the early period, which could play a key role in reperfusion injury of the liver.
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肝虚血再潅流時のKupffer細胞と血小板の動態の解明
阐明肝缺血再灌注期间库普弗细胞和血小板的动态
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi., 森田剛文, Ogawa K., 小川光一, 小川光一, 小川 光一, 小川光一, 小川光一, Tamura T., 田村孝史, 田村孝史, 田村孝史, 田村孝史]
通讯作者:
田村孝史
DOI:
10.3109/09537101003637265
发表时间:
2010-01
期刊:
Platelets
影响因子:
3.3
作者:
[Sugiru Pak;T. Kondo;Y. Nakano;S. Murata;K. Fukunaga;T. Oda;R. Sasaki;N. Ohkohchi]
通讯作者:
Sugiru Pak;T. Kondo;Y. Nakano;S. Murata;K. Fukunaga;T. Oda;R. Sasaki;N. Ohkohchi
DOI:
10.1016/j.jss.2011.12.010
发表时间:
2012-11
期刊:
The Journal of surgical research
影响因子:
--
作者:
[Takafumi Tamura;T. Kondo;Sugiru Pak;Y. Nakano;S. Murata;K. Fukunaga;N. Ohkohchi]
通讯作者:
Takafumi Tamura;T. Kondo;Sugiru Pak;Y. Nakano;S. Murata;K. Fukunaga;N. Ohkohchi
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi., 森田剛文, Ogawa K.]
通讯作者:
Ogawa K.
Kupffer細胞と血小板の類洞内動態に着目した軽度脂肪肝における肝虚血再潅流障害の検討
轻度脂肪肝肝缺血再灌注损伤的检查,重点关注库普弗细胞和血小板的窦内动态
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[S Paku, T Kondo, Y Nakano, S Murata, K Fukunaga, T Oda, R Sasaki, N Ohkohchi., 森田剛文, Ogawa K., 小川光一]
通讯作者:
小川光一
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