Elucidation of the mechanism of transplanted rejected airways with special reference to epithelial to mesenchymal transition

我们证实上皮细胞向间充质细胞的转化在移植的排斥气道中有一定的作用，通过组织学评估随时间的变化。另一方面，我们使用转基因小鼠的结果显示，移植气道纤维化中的成纤维细胞来源于受体。这表明，阻断受体骨髓前体细胞向成纤维细胞分化可能导致防止移植器官中的纤维化。

We confirmed that epithelial to mesenchymal transition had some roles in transplanted rejected airways using histological assessment of changes over time. On the other hand, our results using transgenic mice revealed that the fibroblasts in fibrosis of transplanted airways originated from the recipient. This suggests that blocking fibroblasts differentiation from recipient bone marrow precursor cells may lead to preventing fibrosis in transplanted organs.