POTENT SUPPRESSION OF STRETCH REFLEX ACTIVITY AFTER SYSTEMIC OR SPINAL DELIVERY OF TIZANIDINE IN RATS WITH SPINAL ISCHEMIA -INDUCED CHRONIC SPASTIC PARAPLEGIA

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The aim of this study was to evaluate the therapeutic potency of Tizanidine (Tiz) on stretch reflex activity (SRA) in animals with ischemic spasticity, and to delineate sites of Tiz action. Animals with increased SRA were divided into several experimental subgroups and treated as follows: (i) Tiz administered systemically or Intrathecal (IT) delivered; (ii) treatment with systemic Tiz was followed by vehicle, or by various adrenergic receptor(AR) antagonists; (iii) treatment with IT Tizwas followed by the IT injection of selectiveα2A AR antagonist. Results: systemic and/or IT treatment with Tiz significantly suppressed SRA. This Tiz-mediated anti-SRA effect was reversed byα2A AR, but not α2B AR antegonists. Immunofluorescence staining of spinal cord sections showed upregulation of α2A receptor in activated astrocytes.