Strategy targeting neuropeptide receptors in the central and peripheral nervous systems in treatment of underactive bladder

对糖尿病基因突变小鼠的下尿路功能进行了检测，并与野生型小鼠进行了比较。结果提示，糖尿病小鼠前脑排尿控制机制缺乏相应的抑制功能，表现为反射性排尿。30周龄的糖尿病小鼠仍保持80%以上的排尿效率，尽管存在中度的膀胱活动不足。鞘内注射PACAP-38可增加最大排尿压，部分抑制外括约肌活动，提示刺激脊髓PACAP受体可增强膀胱收缩功能，改善排尿效率。

Lower urinary tract function of genetically mutated mice with diabetes mellitus (DM) was evaluated and compared to that of the wild-type mice. The results suggest that in DM mice, mechanism controlling voiding in the forebrain is devoid of appropriate inhibitory function, and thus the animals present reflex micturition. DM mice at age of 30 week-old still retain voiding efficiency more than 80%, albeit moderately present underactive bladder. Intrathecal administration of PACAP-38 increased maximal voiding pressure and partially suppressed external urethral sphincter activity, suggesting the possibility that stimulation of spinal PACAP receptors enhancesbladder contractility and ameliorates efficiency for voiding.