Effects of endocrinological and immunological factors on metabolism in women during the menopausal transition

绝经过渡期雌激素和卵泡刺激素的变化与参与动脉粥样硬化早期的IL-8和MCP-1的升高有关。此外，睾酮的变化与脂联素和NT-proBNP的变化有关，与胰岛素敏感性有关。自然绝经妇女的这些模式与接受GnRH激动剂治疗的妇女相似。绝经过渡期的变化可能与胰岛素抵抗和动脉粥样硬化的发生有关，部分参与了这些疾病的保护作用。

The changes in estrogen and FSH during the menopausal transition were associated with increases in IL-8 and MCP-1 which were involved in the early stage of atherosclerosis. In addition, the change in testosterone was associatedwith the changes in adiponectin and NT-proBNP related to insulin sensitivity. These patterns in women with natural menopause were similar to those in women with GnRH agonist treatment. The changes during the menopausal transition may be associated with the occurrence of insulin resistance and atherosclerosis, partly be involved in the protective effect of these diseases.