Risk factors of associated with hearing impairment : an epidemiological study

与听力障碍相关的危险因素：流行病学研究

• 批准号: 22591873
• 负责人: SHINKAWA Hideichi
• 金额: $ 2.83万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591873/
• 关键词: 聴覚障害; 大規模調査; アンチエイジング; 動脈硬化; 遺伝子変異

In this study, we showed that hearing worsens with age, and this was especially obvious in males.Our results suggested that vascular sclerosis and osteoporosisare risk factors associated with age related hearing impairment. High pulse wave velocity, a parameter of vascular sclerosis, was related to loss of hearing and decreasing of bone mineral density in females also caused hearing impairment.We confirmed 13 GJB2 gene mutations in this study and also found that 39 of 597 participants (6.53%) were bearers of mutations known to cause hearing impairment.

在这项研究中，我们发现听力随着年龄的增长而下降，这在男性中尤为明显，我们的结果表明血管硬化和动脉硬化是与年龄相关的听力障碍的危险因素。高脉搏波速度是血管硬化的一个参数，与听力损失有关，女性骨密度降低也会导致听力障碍，我们在这项研究中证实了13个GJB2基因突变，并发现597名参与者中有39名（6.53%）携带已知导致听力障碍的突变。

项目成果

AMH(抗ミューラー管ホルモン)と骨密度の関連性についての検討

AMH（抗苗勒氏管激素）与骨密度关系的研究

• 发表时间: 2011
• 作者: Kojimahara T;Nakahara K;Shoji T;Sugiyama T;Takano T;Yaegashi N;Yokoyama Y Mizunuma H;Tase R;Satou H;Tanaka T;Motoyama T;Kurachi H;飯野香理
• 通讯作者: 飯野香理

Epidemiological View of Digestive Cancers in Japan

日本消化道癌症的流行病学观点

• 发表时间: 2010
• 作者: Iwasaki S;Chihara Y;Egami N;Fujimoto C;Murofushi T;Yamasoba T.;Shigeyuki Nakaji
• 通讯作者: Shigeyuki Nakaji

Relationship Between Exhaled Carbon Monoxide Level and Lifestyles in the General Population

一般人群呼出的一氧化碳水平与生活方式之间的关系

• 发表时间: 2011
• 期刊: J Phys Fit Nutr Immunol
• 作者: Ryosuke TSUYA;Takashi UMEDA;Kaori IWANE;Masashi MATSUZAKA;Kazuma DANJO;Ippei TAKAHASHI;Shigeyuki NAKAJI
• 通讯作者: Shigeyuki NAKAJI

Knee osteoarthritis, knee joint pain and aging in relation to increasing serum hyaluronan level in the Japanese population

• DOI: 10.1016/j.joca.2010.10.021
• 发表时间: 2011-01-01
• 期刊: OSTEOARTHRITIS AND CARTILAGE
• 影响因子: 7
• 作者: Inoue, R.;Ishibashi, Y.;Toh, S.
• 通讯作者: Toh, S.

NFLUENCE OF TRACE ELEMENTS WITHIN NORMAL PHYSIOLOGICAL RANGE ON NEUTROPHIL BASAL REACTIVE OXYGEN SPECIES PRODUCTION IN THE JAPANESE GENERAL POPULATION

正常生理范围内的微量元素对日本普通人群中性粒细胞基础活性氧产生的影响

• 发表时间: 2012
• 期刊: 弘前医学
• 作者: Kagami S;Kurita T;Kawagoe T;Toki N,Matsuura Y;Hachisuga T;Matsuyama A;Hashimoto H;Izumi H;Kohno K;伊藤治幸
• 通讯作者: 伊藤治幸