Analysis of the Anti-Atherosclerosis Mechanism of Pioglitazone

我们评估了皮格列酮治疗后，在野生型和脂联素基因敲除小鼠中袖套诱导的动脉新生内膜形成。尽管在吡格列酮治疗3周后仅在野生型小鼠中观察到新生内膜形成的显著改善，但在8周后在野生型小鼠和脂联素敲除小鼠中均观察到。治疗8周后，脂联素基因敲除小鼠的新生内膜形成区的炎症和血管平滑肌细胞的增殖受到抑制。因此，表明吡格列酮通过脂联素依赖性途径和脂联素非依赖性途径改善新生内膜形成。

We assessed cuff-induced neointimal formation of the artery in both wild type and adiponectin knockout mice following pioglitazone treatment. Though significant improvement of neointimal formation was observed only in wild type mice after 3 weeks of pioglitazone treatment, it was observed in both wild type mice and adiponectin knockout mice after 8 weeks. Inflammation in neointimal formation region and proliferation of vascular smooth muscle cells were suppressed by 8 weeks treatment in adiponectin knockout mice. Thus, it is indicated that pioglitazone ameliorates neointimal formation via adiponectin-dependent pathway and adiponectin-independent pathway.