Analysis of the Anti-Atherosclerosis Mechanism of Pioglitazone

我们评估了野生型和脂联素敲除小鼠在吡格列酮治疗后袖带诱导的动脉内膜形成。虽然在吡格列酮治疗3周后，仅在野生型小鼠中观察到新生内膜形成的显著改善，但在8周后，野生型小鼠和脂联素敲除小鼠均观察到新生内膜形成的显著改善。脂联素敲除小鼠8周后，新内膜形成区炎症和血管平滑肌细胞增殖均受到抑制。因此，表明吡格列酮通过脂联素依赖性途径和脂联素非依赖性途径改善新内膜的形成。

We assessed cuff-induced neointimal formation of the artery in both wild type and adiponectin knockout mice following pioglitazone treatment. Though significant improvement of neointimal formation was observed only in wild type mice after 3 weeks of pioglitazone treatment, it was observed in both wild type mice and adiponectin knockout mice after 8 weeks. Inflammation in neointimal formation region and proliferation of vascular smooth muscle cells were suppressed by 8 weeks treatment in adiponectin knockout mice. Thus, it is indicated that pioglitazone ameliorates neointimal formation via adiponectin-dependent pathway and adiponectin-independent pathway.