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Single cell Analysis of asymmetrical cell division of hematopoietic stem cell

Single cell Analysis of asymmetrical cell division of hematopoietic stem cell
造血干细胞不对称细胞分裂的单细胞分析
批准号:
22790920
负责人:
HOSOKAWA Kentaro
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We focused on the distribution of Tie2 on the Pired Daughter Cells(PDCs) of hematopoietic stem cells from the gene expression analysis data. The distribution pattern of Tie2 to PDCs was asymmetrically on steady state, on the other hand, it was symmetrically on the proliferative condition. Moreover, it was suggested that stimulation of Tie2 ligand, Ang-1 shifted the cell division pattern to asymmetric. It will be expected that the operation of cell division pattern of hematopoietic stem cells and stem cell expansion from this research.
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DOI: 10.1016/j.stem.2011.07.003
发表时间: 2011-09-02
期刊: CELL STEM CELL
影响因子: 23.9
作者: [Zou, Peng, Yoshihara, Hiroki, Suda, Toshio]
通讯作者: Suda, Toshio
DOI: 10.1016/j.stem.2009.04.013
发表时间: 2010-03-05
期刊: CELL STEM CELL
影响因子: 23.9
作者: [Hosokawa, Kentaro, Arai, Fumio, Suda, Toshio]
通讯作者: Suda, Toshio
Function of Protection of Telomere (POT1) in the maintenance of hematopoietic stem cells
端粒保护(POT1)在维持造血干细胞中的作用
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Kanitta Srinoun, Kulkeaw Kasem, 水落ちよ, 堀尾有可, 井上朋子, 杉山大介, 細川健太郎]
通讯作者: 細川健太郎
DOI: 10.1182/blood-2009-08-239194
发表时间: 2010-09-02
期刊: BLOOD
影响因子: 20.3
作者: [Nakamura, Yuka, Arai, Fumio, Suda, Toshio]
通讯作者: Suda, Toshio
9
    Challenge to the ex vivo expansion technology of human hematopoietic stem cells by exogenous telomere-binding protein POT1
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