Development of new functional artificial virus contained cancer-selective anticancer drug with the cancer-specific molecules

开发含有癌症特异性分子的癌症选择性抗癌药物的新型功能性人工病毒

• 批准号: 22791255
• 负责人: ONIMARU Manabu
• 金额: $ 2.58万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791255/
• 关键词: 膵癌; 人工ウイルス

We can create a multi-functional artificial virus contained cancer-specific anti-cancer drug. We also evaluated the form and function of this new virus in vitro. We confirmed that artificial virus had been specifically-taken into the pancreatic cancer cell line and had a certain therapeutic effect in comparative experiments in pancreatic cancer cell lines and normal cells in vitro.

我们可以创造一种多功能的人工病毒包含癌症特异性抗癌药物。我们还在体外评估了这种新病毒的形式和功能。通过对胰腺癌细胞株和正常细胞的体外对比实验，证实了人工病毒已特异性地进入胰腺癌细胞株，并具有一定的治疗作用。

项目成果

Adenoviral Therapy Is More Effective in Gemcitabine-resistant Pancreatic Cancer than in Gemcitabine-sensitive Cells.

腺病毒治疗对吉西他滨耐药的胰腺癌比对吉西他滨敏感的细胞更有效。

• 期刊: Anticancer research. in press
• 作者: Takaharu Yasui;Kenoki Ohuchida;Ming Zhao;Lin Cui;Manabu Onimaru;Takuya Egami;Hayato Fujita;Takao Ohtsuka;Kazuhiro Mizumoto;Kunio Matsumoto;Masao Tanaka.
• 通讯作者: Masao Tanaka.

Tumor–stroma interactions reduce the efficacy of adenoviral therapy through the HGF‐MET pathway

• DOI: 10.1111/j.1349-7006.2010.01783.x
• 发表时间: 2011-02
• 期刊: Cancer Science
• 影响因子: 5.7
• 作者: T. Yasui;K. Ohuchida;Ming Zhao;M. Onimaru;Takuya Egami;H. Fujita;T. Ohtsuka;K. Mizumoto;Masao Tanaka

Gencitabime synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in

Gencitabime 通过激活 CMV 启动子来协同增强腺病毒基因治疗的效果

• 发表时间: 2010
• 期刊: pancreatic cancer cells Cancer Gene Ther
• 作者: Onimaru M;Ohuchida K;Egami T;Mizumoto K;Nagai E;Cui L;Toma H;Matsumoto K;Hashizume M;Tanaka M.
• 通讯作者: Tanaka M.

Combination with low-dose gemcitabine andhTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer

与低剂量吉西他滨和 hTERT 启动子依赖性条件复制腺病毒联合使用，通过其串扰机制增强胰腺癌中的细胞毒性

• 发表时间: 2010
• 期刊: Cancer Lett
• 影响因子: 9.7
• 作者: Onimaru M;Ohuchida K;Nagai E,Mizumoto K;Egami T;Tanaka M
• 通讯作者: Tanaka M

Tanaka M Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil

Tanaka M 通过量化与吉西他滨和 5-氟尿嘧啶代谢相关的基因的表达水平来预测胰腺癌细胞的化疗敏感性

• 发表时间: 2011
• 期刊: Int J Oncol
• 影响因子: 5.2
• 作者: Kurata N;Fujita H;Ohuchida K;Mizumoto K;Mahawithitwong P;Sakai H;Onimaru M;Manabe T;Ohtsuka T
• 通讯作者: Ohtsuka T