Association between Epithelial-Mesenchymal transition of pulmonary idiopathic fibrosis and oncogenesis of primary lung carcinoma in human

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1. We investigated EMT-related genes expression(TGF-β1, TGF-β2, TGF-β3, Snail, Sip1, Twist, E-cadherin, N-cadherin and vimentin) in three parts(normal tissue, fiborosis tissue and carcinoma tissue) of the same lobe with idiopathic pulmonary fibrosis. There is no significance in expression level of any genes among three parts. The result did not show a deep association between pulmonary fibrosis and EMT. 2. Next, in our study, prognosis of 4 cases of primary lung carcinoma with idiopathic pulmonary fibrosis was poor than that of 100 cases without idiopathic pulmonary fibrosis. We investigated mRNA expression of EMT-related gene Brachyury and its prognosis. According to five-year disease-free survivals and overall survival rates, Brachyury mRNA expression was a significant prognostic factor for poor patient outcome. Brachyury mRNA was significantly associated to EMT mechanism of up-regulation of IL-8 and Slug and down-regulation of E-Cadherin. However, poor porognosis of primary lung carcinoma with pulmonary idiopathic fibrosis was not due to EMT mechanism by Brachyury gene.