Sex difference of pain and analgesia mechanism. fMRI study

我们通过3-特斯拉功能磁共振成像（fMRI）研究了与甜味诱导镇痛相关的脑激活，其机制被认为涉及中枢神经系统。冷加压试验应用于他们的前臂内侧。在这两种条件下，冷加压试验强烈激活疼痛相关的神经网络，特别是前扣带皮层，丘脑，后顶叶皮层，丘脑，虽然在甜条件下的这种激活减弱与痛阈的增加，与那些在非甜条件下。再加上疼痛评估中的情绪变化，我们的研究结果提供了人类大脑中甜味诱导镇痛的客观表现。

We investigated the brain activation associated with sweet-taste-induced analgesia by 3-tesla functional magnetic resonance imaging (fMRI), the mechanism of which is considered to involve the central nervous system. The cold pressor test was applied to their medial forearm. Under both conditions, the cold pressor test robustly activated the pain-related neural network, notably the anterior cingulate cortex, insula, posterior parietal cortex, and thalamus, although such activations under the sweet condition weakened with pain threshold increase, compared with those under the non-sweet condition. Together with emotional changes in pain appraisal, our findings provide objective representation of sweet-taste-induced analgesia in the human brain.