Effects of local anesthetics on apoptosis in tumor cells.
Effects of local anesthetics on apoptosis in tumor cells.
局部麻醉药对肿瘤细胞凋亡的影响。
批准号：
22791446
负责人：
TAMURA Ryuji
金额：
$2.75万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
中文摘要
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英文摘要
The aim of this study was to clarify the local anesthetics that induce apoptosis or necrosis and their induction-related factors.Methods : Apoptosis and necrosis were analyzed by double-staining assay with propidium iodide(PI) and annexin-V and were measured by flow cytometry(FACS). DNA fragmentation was used for the analysis of apoptosis.Conclusion : The results indicate that local anesthetics with high lipophilicity are highly toxic and induce mainly necrosis, while local anesthetics with low pKa induce more apoptosis.
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会议论文
DOI：
10.1213/ane.0b013e318204ea5b
发表时间：
2011-03-01
期刊：
ANESTHESIA AND ANALGESIA
影响因子：
5.7
作者：
[Onizuka, Shin, Yonaha, Tetsu, Tsuneyoshi, Isao]
通讯作者：
Tsuneyoshi, Isao
Study on the long-range mangetic order formed by rare-earth spin icosahedra
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批准号：24560808
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项目类别：Grant-in-Aid for Scientific Research (C)
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资助金额：$3.41万
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财政年份：2012
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负责人：TAMURA Ryuji
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依托单位：
Effects of anesthetics on intracellular glucose concentration
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批准号：24791604
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.75万
-
财政年份：2012
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负责人：TAMURA Ryuji
-
依托单位：
Study on the orientational ordering of the tetrahedron inside anicosahedral cluster
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批准号：21760522
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项目类别：Grant-in-Aid for Young Scientists (B)
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资助金额：$2.83万
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财政年份：2009
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负责人：TAMURA Ryuji
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依托单位：
海外基金
