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Biological significance of expression of aryl hydrocarbon receptor in bladder cancer

Biological significance of expression of aryl hydrocarbon receptor in bladder cancer
膀胱癌中芳烃受体表达的生物学意义
批准号:
22791494
负责人:
ISHIDA Masaru
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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项目成果

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中文摘要
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英文摘要
In clinicopathological study, the expression of aryl hydrocarbon receptor(AhR) significantly associated with lymphovascular invasion which is prognostic factor of urothelial cancer. The regulation of the expression of AhR correlated with the expression of matrix metalloproteinase(MMP) in in vitro study. Furthermore, the invasion activity of bladder cancer cell was affected by the expression status of AhR.
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Activation of the AhR pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer
AhR 通路的激活通过上调尿路上皮癌中 MMP 的表达来增强癌细胞的侵袭
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ishida M, Mikami S, Kikuchi E, Kosaka T, Miyajima A, Nakagawa K, Mukai M, Okada Y, Oya M]
通讯作者: Oya M
Activation of the aryl hydrocarbon receptor is associated with cigarette smoke, poor prognosis and cancer cell invasion in renal cell carcinoma.
芳烃受体的激活与肾细胞癌中的香烟烟雾、不良预后和癌细胞侵袭有关。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Ishida M., Mikami S., Kosaka T., Kono H., Kikuchi E., Nagata H., Miyajima A., Nakagawa K., Mukai M., Okada Y., Oya M.]
通讯作者: Oya M.
Metastin, the final peptide of KISS-1 gene, prevents lung metastases of murine bladder cancer
KISS-1 基因的最终肽 Metastin 可预防小鼠膀胱癌的肺转移
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takeda T, Kikuchi E, Suzuki E, Ito Y, Ishida M, Matsumoto K, Miyajima A, Mikami S, Oya M]
通讯作者: Oya M
Activation of aryl hydrocarbon receptor promotes epithelial-mesenchymal transition of renal cell carcinoma by inducing Slug and matrix metalloproteinases.
芳烃受体的激活通过诱导Slug和基质金属蛋白酶促进肾细胞癌的上皮-间质转化。
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Takeda T, Kikuchi E, Suzuki E, Ito Y, Ishida M, Matsumoto K, Miyajima A, Mikami S, Oya M, Masaru Ishida]
通讯作者: Masaru Ishida
6
    Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes: Implications for cancer invasion, prognosis and tumor immunity
    • 批准号:
      24791668
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.75万
    • 财政年份:
      2012
    • 负责人:
      ISHIDA Masaru
    • 依托单位:
    Development of chromatography System for multi components with high-yield, high-purity, high-concentration and high-productivity
    • 批准号:
      15360409
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $6.66万
    • 财政年份:
      2003
    • 负责人:
      ISHIDA Masaru
    • 依托单位:
    Development of High-performance Chemical-looping Combustion
    • 批准号:
      11555198
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $8.0万
    • 财政年份:
      1999
    • 负责人:
      ISHIDA Masaru
    • 依托单位:
    Development of Combustor with CO_2 Capturing by Alternately Changing Fuel and Air Streams
    • 批准号:
      11450298
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
      $8.64万
    • 财政年份:
      1999
    • 负责人:
      ISHIDA Masaru
    • 依托单位:
    国内基金
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    基于“人源化”新型近红外荧光探针的构建及其在膀胱癌诊疗一体化中的应用研究
    RPS27a类泛素化修饰GOLPH3诱导高尔基体自噬介导Apelin-13促人膀胱癌细胞的增殖和迁移
    • 批准号:
      2026JJ80179
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      刘世敏
    • 依托单位:
    功能化纳米佐剂的制备及其用于膀胱癌放疗增敏的机制研究
    • 批准号:
    • 项目类别:
      省市级项目
    • 资助金额:
      --
    • 批准年份:
      2026
    • 负责人:
      熊伟
    • 依托单位:
    ALKBH5 通过表观调控抑制膀胱癌转移的机 制研究及类器官辅助精准治疗策略