Biological significance of expression of aryl hydrocarbon receptor in bladder cancer

膀胱癌中芳烃受体表达的生物学意义

• 批准号: 22791494
• 负责人: ISHIDA Masaru
• 金额: $ 2.58万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791494/
• 关键词: 腫瘍学; 膀胱癌; 芳香族炭化水素受容体; 浸潤; 発癌

In clinicopathological study, the expression of aryl hydrocarbon receptor(AhR) significantly associated with lymphovascular invasion which is prognostic factor of urothelial cancer. The regulation of the expression of AhR correlated with the expression of matrix metalloproteinase(MMP) in in vitro study. Furthermore, the invasion activity of bladder cancer cell was affected by the expression status of AhR.

在临床病理研究中，芳烃受体（AhR）的表达与尿路上皮癌的淋巴管浸润密切相关，是尿路上皮癌的预后因素。体外研究发现AhR的表达调控与基质金属蛋白酶（MMP）的表达相关。AhR的表达状态影响膀胱癌细胞的侵袭能力。

项目成果

Activation of the AhR pathway enhances cancer cell invasion by up-regulating the MMP expression in urothelial cancer

AhR 通路的激活通过上调尿路上皮癌中 MMP 的表达来增强癌细胞的侵袭

• 发表时间: 2010
• 作者: Ishida M;Mikami S;Kikuchi E;Kosaka T;Miyajima A;Nakagawa K;Mukai M;Okada Y;Oya M
• 通讯作者: Oya M

Activation of the aryl hydrocarbon receptor is associated with cigarette smoke, poor prognosis and cancer cell invasion in renal cell carcinoma.

芳烃受体的激活与肾细胞癌中的香烟烟雾、不良预后和癌细胞侵袭有关。

• 发表时间: 2010
• 作者: Ishida M.;Mikami S.;Kosaka T.;Kono H.;Kikuchi E.;Nagata H.;Miyajima A.;Nakagawa K.;Mukai M.;Okada Y.;Oya M.
• 通讯作者: Oya M.

Metastin, the final peptide of KISS-1 gene, prevents lung metastases of murine bladder cancer

KISS-1 基因的最终肽 Metastin 可预防小鼠膀胱癌的肺转移

• 发表时间: 2011
• 作者: Takeda T;Kikuchi E;Suzuki E;Ito Y;Ishida M;Matsumoto K;Miyajima A;Mikami S;Oya M
• 通讯作者: Oya M

Activation of aryl hydrocarbon receptor promotes epithelial-mesenchymal transition of renal cell carcinoma by inducing Slug and matrix metalloproteinases.

芳烃受体的激活通过诱导Slug和基质金属蛋白酶促进肾细胞癌的上皮-间质转化。

• 发表时间: 2011
• 作者: Takeda T;Kikuchi E;Suzuki E;Ito Y;Ishida M;Matsumoto K;Miyajima A;Mikami S;Oya M;Masaru Ishida
• 通讯作者: Masaru Ishida

Transumbilical laparo-endoscopic single site surgery for adrenal cortical adenoma inducing primary aldosteronism : initial experience

经脐腹腔镜单部位手术治疗诱发原发性醛固酮增多症的肾上腺皮质腺瘤：初步经验

• 发表时间: 2011
• 期刊: BMC Research Notes
• 影响因子: 1.8
• 作者: 宮嶋哲、石田勝;ら
• 通讯作者: ら