Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes: Implications for cancer invasion, prognosis and tumor immunity

透明细胞肾细胞癌和浸润淋巴细胞中芳烃受体表达增加：对癌症侵袭、预后和肿瘤免疫的影响

• 批准号: 24791668
• 负责人: ISHIDA Masaru
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791668/
• 关键词: 腎細胞癌; 芳香族炭化水素受容体; 浸潤; 発癌; 腫瘍浸潤リンパ球

AhR in RCC was significantly associated with the smoking history, gender and histological grade. The number of AhR-positive TIL was significantly associated with histological grade and pathological T stage. In tumor tissues, the number of T cell was significantly higher than that of B cell. In the patients who have poor prognosis, the number of helper T cell was significantly higher than that of cytotoxic T cell. Furthermore, in those patients AhR-positive TIL and regulatory T cell more infiltrated in tumor adjacent tissues than in tumor tissues. The AhR expression in TIL was a significant predictor for progression free survival. A multivariate analysis revealed that AhR in cancer cells was an independent prognostic factor for the progression free survival and disease specific survival.These results suggest that AhR may be involved in tumor immunity.

肾癌组织中AhR与吸烟史、性别、组织学分级显著相关。AhR阳性TIL的数量与组织学分级和病理T分期显著相关。肿瘤组织中T细胞明显多于B细胞。在预后不良的患者中，辅助性T细胞的数量明显高于细胞毒性T细胞。癌旁组织中AhR阳性的TIL和调节性T细胞的浸润明显多于癌组织。TIL中AhR表达是无进展生存期的显著预测因子。多因素分析显示癌细胞AhR是影响无进展生存期和疾病特异性生存期的独立预后因素，提示AhR可能参与肿瘤免疫。

项目成果

慶應義塾大学医学部 泌尿器科学教室 業績紹介

庆应义塾大学医学院泌尿外科成果介绍

Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes: Implications for cancer invasion, prognosis and tumor immunity

透明细胞肾细胞癌和浸润淋巴细胞中芳烃受体表达增加：对癌症侵袭、预后和肿瘤免疫的影响

• 发表时间: 2014
• 作者: Ishida M;Mikami S;Kosaka T;Mizuno R;Kikuchi E;Miyajima A;Nakagawa K;Okada Y;Oya M
• 通讯作者: Oya M

The Prognostic Significance of Vasohibin-1 Expression in Patients with Upper Urinary Tract Urothelial Carcinoma

• DOI: 10.1158/1078-0432.ccr-12-0073
• 发表时间: 2012-08-01
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Miyazaki, Yasumasa;Kosaka, Takeo;Oya, Mototsugu
• 通讯作者: Oya, Mototsugu

Increased expression of aryl hydrocarbon receptor in clear cell renal cell carcinoma and infiltrating lymphocytes : Implications for cancer invasion, prognosis and tumor immunity

透明细胞肾细胞癌和浸润淋巴细胞中芳烃受体表达增加：对癌症侵袭、预后和肿瘤免疫的影响

• 发表时间: 2014
• 作者: Ishida M;Mikami S;Kosaka T;Mizuno R;Kikuchi E;Miyajima A;Nakagawa K;Okada Y;Oya M
• 通讯作者: Oya M