The mechanism of allo-grafted cell Rejection by Allo-Induced Macrophages

同种异体诱导巨噬细胞排斥异体移植细胞的机制

• 批准号: 22791504
• 负责人: NOMI Hayahito
• 金额: $ 2.41万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791504/
• 关键词: ｱﾛﾏｸﾛﾌｧｰｼﾞ; 急性拒絶反応; 免疫寛容; 同異種系移植; マウス; ﾏｸﾛﾌｧｰｼﾞ; effector; 同種異系移植; アロ活性化マクロファージ; 拒絶反応; NK細胞; 同種移植; 既活性化マクロファージ; AIM

The effector cells of allo-rejection has been to be killer T cells (CTL) or NK cells. However, several events which CTL cannot producing some allograft rejections have also been reported. We have shown that allo-activated macrophages are the major effector of some allograft rejections. We confirmed that the allo-cytotoxic activity is higher in Mac-1 positive fraction, which is a surface marker of macrophage, than in NK1.1-positive fraction of effector cells through the rejection of allo-grafted Meth A fibrosarcoma cells grafted into the abdominal cavity of mice. In addition, to obtain the results suggest that activated macrophage is the effector cell from the fact that the cytotoxic activity of peritoneal infiltration cell of allograft after slightly higher with antibodies against Meth A cells, in vitro.

同种异体排斥反应的效应细胞一直是杀伤T细胞(CTL)或NK细胞。然而，CTL不能产生一些同种异体移植排斥反应的几个事件也有报道。我们已经证明，同种异体激活的巨噬细胞是一些同种异体移植排斥反应的主要效应者。我们通过对移植到小鼠腹腔内的Meth A纤维肉瘤细胞的排斥反应，证实了巨噬细胞表面标志Mac-1阳性组分的同种异体细胞毒活性高于NK1.1阳性效应细胞组分。另外，为了获得上述结果提示，活化的巨噬细胞是效应细胞，从事实上来说，同种异体移植后的腹膜浸润细胞的细胞毒活性略高于抗Meth A细胞的抗体，在体外。

项目成果

腎移植の概要と最近の動向について大腎協

日本肾脏协会提供肾移植的概述和最新趋势。

• 发表时间: 2013
• 作者: Yoshida K;Iwamoto T;Yoshida M;能見 勇人
• 通讯作者: 能見 勇人

腎移植の概要と最近の動向について

肾移植概述及最新趋势

• 发表时间: 2013
• 作者: Yoshida K;Iwamoto T;Yoshida M;能見 勇人;能見勇人
• 通讯作者: 能見勇人