Analysis of protein expression of uterine sarcoma by iTRAQ method
Analysis of protein expression of uterine sarcoma by iTRAQ method
批准号:
22791530
负责人:
UEDA Yutaka
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
我们利用iTRAQ方法和免疫组织化学方法,对子宫肌肉瘤和正常子宫肌层的临床标本进行分析,发现C蛋白在子宫肌肉瘤中的表达较正常子宫肌层特异性增加,而L蛋白在子宫肌肉瘤中的表达较正常子宫肌层特异性降低。目前,我们正在分析这些蛋白质的功能。
英文摘要
We identified Protein C whose expression was specifically increased in leiomyosarcoma compared to normal myometrium and Protein L whose expression was specifically reduced in leiomyosarcoma compared to normal myometrium, by iTRAQ method and immunohistochemistry using clinical samples of uterine leiomyosarcoma and normal myometrium. Currently we are analyzing functions of these proteins.
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依托单位:
海外基金