Multilateral study of prestin expression and function in mouse choclear outer hair cell

电压依赖性，非线性电容（Cv），这代表的构象波动的电机分子，在发展过程中逐步增加，而临床，这代表OHC的膜面积，保持一个相对较小的增加与发展。R75 W转基因小鼠和非转基因小鼠中Cv和Clin的时间进程没有显示出显著差异，进一步表明它们与C57 BL/6 J小鼠中的Cv和Clin的时间进程几乎相同（Abe等人，2007年）。使用数字捕获的相位衬度图像的形态学研究显示，R75 W转基因小鼠和C57 BL/6 J小鼠之间没有显着差异。我们的研究结果表明，OHC运动功能的发展是不受影响的R75 W转基因小鼠。

Voltage-dependent, nonlinear capacitance (Cv), which represents the conformational fluctuations of the motor molecule, progressively increased during development while Clin, which represents the membrane area of OHC, remained a relatively small increase with development. The time course of Cv and Clin in R75W transgenic mice and non-transgenic mice showed no significant difference, further showing that they were almost identical to that in C57BL/6J mice (Abe et al., 2007). Morphological study using digitally captured phase-contrast images of developing OHCs showed no significant difference between R75W transgenic mice and C57BL/6J mice. Our results indicate that development of OHC motility function is not affected in R75W transgenic mice.