Multilateral study of prestin expression and function in mouse choclear outer hair cell

点击翻译按钮获取中文摘要

Voltage-dependent, nonlinear capacitance (Cv), which represents the conformational fluctuations of the motor molecule, progressively increased during development while Clin, which represents the membrane area of OHC, remained a relatively small increase with development. The time course of Cv and Clin in R75W transgenic mice and non-transgenic mice showed no significant difference, further showing that they were almost identical to that in C57BL/6J mice (Abe et al., 2007). Morphological study using digitally captured phase-contrast images of developing OHCs showed no significant difference between R75W transgenic mice and C57BL/6J mice. Our results indicate that development of OHC motility function is not affected in R75W transgenic mice.