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Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration

Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration
内耳感觉上皮基因表达的综合分析及其在再生中的应用
批准号:
22791595
负责人:
YAMAMOTO Norio
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We performed preliminary experiments to set up the condition of extracting RNA from single cochlear cells and amplifying the cDNA linearly. In addition, we found the function of several genes in the cochlea. These results will contribute to the realization of cochlear regenerative medicine. Complete inhibition of Notch signaling in the mouse cochlear caused small numbers of inner hair cells only in the apical turn. This result indicates that Notch signaling is involved not only in the determination of cell fate but also in the maintenance of the cochlear sensory epithelial progenitors. The analysis of EP4 knockout mice revealed that prostaglandin E physiologically protects cochlear hair cells. We also found the new markers of cochlear supporting cells, Septin4, Septin5, and Septin7.
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DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Yamamoto, Norio; Hamaguchi, Kiyomi; Nakagawa, Takayuki; Ito, Juichi, 山本典生; 平海晴一; 坂本達則; 伊藤壽一]
通讯作者: 山本典生; 平海晴一; 坂本達則; 伊藤壽一
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发表时间: 2010
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Yamamoto N, Okuyama H, Hiraumi H, Sakamoto T, Ito J]
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DOI: 10.1007/s00405-012-2004-9
发表时间: 2013-02-01
期刊: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
影响因子: 2.6
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通讯作者: Ito, Juichi
17
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