课题基金 / 基金详情

Regulation of SARS-CoV replication by cyclophilin

Regulation of SARS-CoV replication by cyclophilin
亲环蛋白对 SARS-CoV 复制的调节
批准号:
20590467
负责人:
YAMAMOTO Norio
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

YAMAMOTO Norio的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
To investigate the relationship between cyclophilin and SARS-CoV replication, we introduced shRNA expression vectors to cells and compare the virus titer produced from these cells. Efficiency of SARS-CoV replication was much lower in the cells expressing shRNA against cyclophilin A and B than in the cells expressing control shRNA. The results of time-of-addition assay and entry assay showed that cyclosporin A inhibited SARS-CoV replication at the post-entry step in viral life cycle. These results suggested that cyclophilins could play a role as positive regulators of SARS-CoV replication at the post-entry step.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [原崎一浩, 永田典代, 岩田奈織子, 長谷川秀樹, 佐多徹太郎, 山本直樹, 高久 洋, 佐藤人美, 山本陽子, 平松啓一, 田代眞人, 山本典生]
通讯作者: 山本典生
DOI: --
发表时间:
期刊:
影响因子: --
作者: []
通讯作者:
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.
SARS-CoV 和 ACE2 的刺突蛋白对 TNF-α 转换酶的调节诱导 TNF-α 产生并促进病毒进入。
DOI: --
发表时间: 2008
期刊: Proc Natl Acad Sci U S A 105(22)
影响因子: --
作者: [Haga S, Yamamoto N, Nakai-Murakami C, Osawa Y, Tokunaga K, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y]
通讯作者: Ishizaka Y
HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses
HIV-1 RT依赖性DNA酶表达抑制HIV-1复制而不出现逃逸病毒
DOI: --
发表时间: 2010
期刊: Nucleic Acids Res.
影响因子: --
作者: [Ryuichi Sugiyama, Masaaki Hayafune, Y. Habu, N. Yamamoto, H. Takaku]
通讯作者: H. Takaku
8
    Tranlational research for the improved outcome and the broader indication of the cochlear implantation
    • 批准号:
      24592545
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.41万
    • 财政年份:
      2012
    • 负责人:
      YAMAMOTO Norio
    • 依托单位:
    Efficacy of newly developed platinum complexes against osteosarcoma, bone targeting platinum and proteasome inhibitory platinum.
    • 批准号:
      23592180
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2011
    • 负责人:
      YAMAMOTO Norio
    • 依托单位:
    Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration
    • 批准号:
      22791595
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $2.58万
    • 财政年份:
      2010
    • 负责人:
      YAMAMOTO Norio
    • 依托单位:
    An Anthropological Study of Environmental Exploitation in the Andes
    • 批准号:
      13371010
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $26.04万
    • 财政年份:
      2001
    • 负责人:
      YAMAMOTO Norio
    • 依托单位:
    海外基金