Regulation of SARS-CoV replication by cyclophilin
Regulation of SARS-CoV replication by cyclophilin
批准号:
20590467
负责人:
YAMAMOTO Norio
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
To investigate the relationship between cyclophilin and SARS-CoV replication, we introduced shRNA expression vectors to cells and compare the virus titer produced from these cells. Efficiency of SARS-CoV replication was much lower in the cells expressing shRNA against cyclophilin A and B than in the cells expressing control shRNA. The results of time-of-addition assay and entry assay showed that cyclosporin A inhibited SARS-CoV replication at the post-entry step in viral life cycle. These results suggested that cyclophilins could play a role as positive regulators of SARS-CoV replication at the post-entry step.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
免疫抑制剤のSARSコロナウイルス増殖に与える影響についての解析
免疫抑制剂对SARS冠状病毒增殖的影响分析
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[原崎一浩, 永田典代, 岩田奈織子, 長谷川秀樹, 佐多徹太郎, 山本直樹, 高久 洋, 佐藤人美, 山本陽子, 平松啓一, 田代眞人, 山本典生]
通讯作者:
山本典生
ホームページ等。
主页等
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.
SARS-CoV 和 ACE2 的刺突蛋白对 TNF-α 转换酶的调节诱导 TNF-α 产生并促进病毒进入。
DOI:
--
发表时间:
2008
期刊:
Proc Natl Acad Sci U S A 105(22)
影响因子:
--
作者:
[Haga S, Yamamoto N, Nakai-Murakami C, Osawa Y, Tokunaga K, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y]
通讯作者:
Ishizaka Y
HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses
HIV-1 RT依赖性DNA酶表达抑制HIV-1复制而不出现逃逸病毒
DOI:
--
发表时间:
2010
期刊:
Nucleic Acids Res.
影响因子:
--
作者:
[Ryuichi Sugiyama, Masaaki Hayafune, Y. Habu, N. Yamamoto, H. Takaku]
通讯作者:
H. Takaku
DOI:
10.1016/j.antiviral.2009.12.001
发表时间:
2010-03
期刊:
Antiviral research
影响因子:
7.6
作者:
[Haga S, Nagata N, Okamura T, Yamamoto N, Sata T, Yamamoto N, Sasazuki T, Ishizaka Y]
通讯作者:
Ishizaka Y
共 8 条
Tranlational research for the improved outcome and the broader indication of the cochlear implantation
-
批准号:24592545
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2012
-
负责人:YAMAMOTO Norio
-
依托单位:
Efficacy of newly developed platinum complexes against osteosarcoma, bone targeting platinum and proteasome inhibitory platinum.
-
批准号:23592180
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:YAMAMOTO Norio
-
依托单位:
Comprehensive profiling of the gene expression in the inner ear sensory epithelium and its application to the regeneration
-
批准号:22791595
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2010
-
负责人:YAMAMOTO Norio
-
依托单位:
An Anthropological Study of Environmental Exploitation in the Andes
-
批准号:13371010
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$26.04万
-
财政年份:2001
-
负责人:YAMAMOTO Norio
-
依托单位:
Ethnological Study of Grassland and Forest Use in Nepal Himalaya
-
批准号:06041126
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$10.11万
-
财政年份:1994
-
负责人:YAMAMOTO Norio
-
依托单位:
Ethnological Studies on Environmental Exploitation in Mountains - The Nepal Himalays and the Central Andes Compared-
-
批准号:02041100
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$2.56万
-
财政年份:1990
-
负责人:YAMAMOTO Norio
-
依托单位:
海外基金