the elucidation of recurrence and malignant alteration mechanism of inverted papilloma

鼻窦内翻性乳头状瘤是一种良性肿瘤，但临床上存在两个问题。IP易复发（术后复发率20%），有恶性转化的可能（约10%）。本研究的最终目的是评估手术前复发和恶性转化的可能性。患者血清中鳞状细胞癌抗原（SCCA）的检测对诊断IP的存在和复发及病理检查有重要意义。鼻窦炎中SCCA2/1 mRNA的表达比例与鼻窦炎相当，而鼻旁癌中SCCA2/1的表达比例明显高于鼻旁癌。组织中SCCA2/1比值提示IP可能发生恶性转化。由于HPV在IP中的存在率为46.1%，HPV具有制造IP的潜力，HPV的整合也会导致IP的恶性转化。

Although sinonasal inverted papilloma (IP) is one of the benign tumor, there are two clinical problems about it. IP is easy to recur (the rate of recurrence after operation: 20%), and has a potential of malignant transformation (approximately 10%). The final goal of this study is to evaluate the potential of recurrence and malignant transformation before surgery. The squamous cell carcinoma antigen (SCCA) in IP patient's serum was useful to diagnosis of IP presence and recurrence as well as pathologic examination. The SCCA2/1 ratio of mRNA expression in IP was equivalent to those in sinusitis, while paranasal cancer demonstrated the significantly higher SCCA2/1 ratio. The SCCA2/1 ratio in tissue may indicate the possible malignant transformation of IP. Since the HPV presence rate in IP was 46.1%, HPV has a potential of making IP and integration of HPV also causes the malignant transformation of IP.